Radial modulation contrast imaging using a 20-MHz single-element intravascular ultrasound catheter.
Radial modulation contrast imaging using a 20-MHz single-element intravascular ultrasound catheter.
复制标题
使用 20 MHz 单元件血管内超声导管进行径向调制对比成像。
DOI：
10.1109/tuffc.2014.6805692
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Chen,Xucai
中科院分区：
文献类型：
--
作者：
Yu,FrancoisTH;Villanueva,FlordelizaS;Chen,Xucai
Contrast-enhanced intravascular ultrasound imaging is a promising tool for the characterization of coronary vasa vasorum proliferation, which has been identified as a marker of, and possible etiologic factor in, the development of high-risk atherosclerotic plaques. Resonance-based nonlinear detection methods have required the development of prototype catheters which are not commercially available, thus limiting clinical translation. In this study, we investigated the performances of a radial modulation imaging approach (25/3 MHz combination) using simulations, implemented it on a clinical 20-MHz rotating catheter, and tested it in a wall-less tissuemimicking flow phantom perfused with lipid-encapsulated microbubbles (MBs). The effects of the phase lag, low-frequency pressure, and MB concentration on the envelope subtracted radial modulation signals were investigated as a function of depth. Our dual-pulse dual-frequency approach produced contrast- specific images with contrast-to-tissue improvements over B-mode of 15.1 ± 2.1 dB at 2 mm and 6.8 ± 0.1 dB at 4 mm depths. Using this imaging strategy, 200-μm-diameter cellulose tubing perfused with MBs could be resolved while surrounding tissue scattering was suppressed. These results raise promise for the detection of coronary vasa vasorum and may ultimately facilitate the detection of plaque at risk for rupture.
