CARBON-MONOXIDE - A PUTATIVE NEURAL MESSENGER
CARBON-MONOXIDE - A PUTATIVE NEURAL MESSENGER
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DOI：
10.1126/science.7678352
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发表时间：
1993-01-15
期刊：
影响因子：
56.9
通讯作者：
SNYDER, SH
中科院分区：
文献类型：
--
作者：
VERMA, A;HIRSCH, DJ;SNYDER, SH
一氧化碳是鸟苷酸环化酶的激活剂，由血红素加氧酶的作用形成。通过在脑切片中的原位杂交，已经证明了血红素加氧酶的组成形式的信使RNA在整个脑中的离散神经元定位。这种定位基本上与可溶性鸟苷酸环化酶信使RNA的定位相同。在嗅神经元的原代培养物中，锌原卟啉-9（一种有效的血红素加氧酶的选择性抑制剂）耗尽内源性鸟苷3 '，5'-单磷酸（cGMP）。因此，一氧化碳，像一氧化氮，可能是cGMP的生理调节剂。这些发现，加上血红素加氧酶的神经元定位，表明一氧化碳可能作为一种神经递质。
Carbon monoxide, an activator of guanylyl cyclase, is formed by the action of the enzyme heme oxygenase. By in situ hybridization in brain slices, discrete neuronal localization of messenger RNA for the constitutive form of heme oxygenase throughout the brain has been demonstrated. This localization is essentially the same as that for soluble guanylyl cyclase messenger RNA, In primary cultures of olfactory neurons, zinc protoporphyrin-9, a potent selective inhibitor of heme oxygenase, depletes endogenous guanosine 3',5'-monophosphate (cGMP). Thus, carbon monoxide, like nitric oxide, may be a physiologic regulator of cGMP. These findings, together with the neuronal localizations of heme oxygenase, suggest that carbon monoxide may function as a neurotransmitter.