Cyclical passive stretch influences the mechanical properties of the inactive cat soleus
Cyclical passive stretch influences the mechanical properties of the inactive cat soleus
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DOI：
10.1113/expphysiol.1998.sp004121
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发表时间：
1998-05-01
影响因子：
2.7
通讯作者：
Edgerton, VR
中科院分区：
文献类型：
--
作者：
Roy, RR;Pierotti, DJ;Edgerton, VR
在5只猫中测定了周期性被动操作（PM，30分钟/天（-1），5天/周（-1），持续6个月）模仿在步行过程中观察到的长度偏移对不活动猫比目鱼肌的机械和相关生化特性的影响。通过脊髓隔离（SI），即在低胸椎和高骶骨水平完全横断脊髓，并在横断部位之间进行双侧背根切断术，产生不活动。与正常对照组相比，SI猫的体重下降了70%，最大强直张力（P-0）下降了80%，最大缩短率（V-max）和肌球蛋白腺苷三磷酸酶（mATP酶）活性增加了100%。被动操作制度部分改善了这些影响。与对照组相比，SI-PM比目鱼肌重量和最大强直张力分别高12%和21%，V-max和mATPase活性分别低21%和12%（p > 0.05）。因此，不活动导致更小和更快的肌肉，而每天仅30分钟的被动操作倾向于保持这些属性接近正常对照值。结果表明，短时间的周期性被动操作对其他不活动的骨骼肌有潜在的治疗作用。
The effects of cyclical, passive manipulation (PM, 30 min day(-1), 5 days week(-1) for 6 months) mimicking the length excursions observed during stepping on the mechanical and associated biochemical properties of the inactive cat soleus muscle were determined in five cats. Inactivity was produced via spinal cord isolation (SI), i.e. complete spinal cord transections at low thoracic and high sacral levels and bilateral dorsal rhizotomy between the transection sites. Passive manipulation was administered to one leg of each SI cat. Compared with normal controls, SI resulted in similar to 70 % decrease in weight, an 80 % decrease in maximum tetanic tension (P-0) and an similar to 100% increase in maximum rate of shortening (V-max) and myosin adenosine triphosphatase (mATPase) activity of the soleus. The passive manipulation regime partially ameliorated these effects. When compared with the control SI soleus, the SI-PM soleus weight and maximum tetanic tension were 12 and 21 % higher, respectively, and the V-max and mATPase activity 21 and 12% (p > 0.05) lower, respectively. Thus, inactivity resulted in a smaller and faster muscle, whereas passive manipulation for only 30 min a day tended to maintain these properties closer to normal control values. The results suggest a potential therapeutic effect of short bouts of cyclical, passive manipulation on otherwise inactive skeletal muscles.