WOUND CLOSURE - EVIDENCE OF COOPERATION BETWEEN FIBROBLASTS AND COLLAGEN MATRIX
WOUND CLOSURE - EVIDENCE OF COOPERATION BETWEEN FIBROBLASTS AND COLLAGEN MATRIX
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DOI：
10.1038/eye.1988.28
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发表时间：
1988-01-01
期刊：
影响因子：
3.9
通讯作者：
EHRLICH, HP
中科院分区：
文献类型：
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作者：
EHRLICH, HP
其中活组织已被创伤破坏的严重伤口的闭合涉及新的结缔组织基质的沉积，其量由创伤的严重程度决定。新的结缔组织基质是不成熟的，在某些情况下，可以减少自己。当这发生在愈合的伤口时，它被称为伤口收缩。当它发生在愈合伤口的疤痕中时，它被称为疤痕挛缩。成纤维细胞中产生的力组织周围的结缔组织基质，这是伤口收缩和瘢痕挛缩的原因。这里提出的实验工作支持这样的想法，即这些收缩力驻留在成纤维细胞的工作作为单独的单位收缩伤口。没有证据支持肌成纤维细胞（一种专门的细胞）负责收缩力的想法。应力纤维的形态学外观表明肌成纤维细胞的存在，实际上可能意味着收缩力产生的终止。细胞收缩力的控制似乎与结缔组织基质的组成有关。富含III型胶原蛋白的基质比由I型胶原蛋白制成的基质收缩更快且程度更大。这表明，肉芽组织和不成熟的疤痕与富含III型胶原的基质将更容易收缩比一个更成熟的疤痕与较少的III型胶原。来自体外模型的证据表明，成纤维细胞产生收缩力，而胶原蛋白控制伤口闭合和瘢痕挛缩中的这些力。
The closure of severe wounds where viable tissue has been destroyed by trauma involves the depositing of a new connective tissue matrix, the amount of which is dictated by the severity of trauma. That new connective tissue matrix is immature, and in some cases, can reduce itself. When this occurs in a healing wound it is called wound contraction. When it occurs in the scar of a healed wound, it is called scar contracture. Forces generated in fibroblasts organise the surrounding connective tissue matrix, and this is responsible for the contraction of wounds and the contracture of scars. The experimental work presented here supports the idea that these contractile forces residing in the fibroblast work as individual units to contract the wound. There is no evidence to support the idea of the myofibroblast, a specialised cell, being responsible for contractile forces, as reported. The morphological appearance of stress fibres, which denote the presence of myofibroblasts, may, in fact, signify the termination of the generation of contractile forces. Control of cellular contractile forces appears to be linked to the composition of the connective tissue matrix. A matrix rich in type III collagen contracts faster and to a greater degree than one made from type I collagen. It is suggested that granulation tissue and immature scar with a matrix rich in type III collagen will contract more readily than a more mature scar with less type III collagen. Evidence presented from in vitro models suggests that fibroblasts generate the forces of contraction, and collagen controls those forces in wound closure and scar contracture.