Bacteriophage AB-SA01 Cocktail in Combination with Antibiotics against MRSA-VISA Strain in an In Vitro Pharmacokinetic/Pharmacodynamic Model
Bacteriophage AB-SA01 Cocktail in Combination with Antibiotics against MRSA-VISA Strain in an In Vitro Pharmacokinetic/Pharmacodynamic Model
复制标题
DOI：
10.1128/aac.01863-20
复制
发表时间：
2021-01-01
影响因子：
4.9
通讯作者：
Rybak, Michael J.
中科院分区：
文献类型：
--
作者：
Kebriaei, Razieh;Lev, Katherine L.;Rybak, Michael J.
本研究旨在检测噬菌体-抗生素组合（BAC）在体外24 h时间杀灭环境中的有效性，以及在体外模拟内皮生长（SEV）药代动力学/药效学模型中96 h的有效性。BAC阻止了噬菌体抗性的发展，而一些噬菌体抗性出现在单独的噬菌体处理中。此外，BAC导致SEV模型中细菌根除的增强。我们的研究结果支持BAC治疗对抗严重耐甲氧西林金黄色葡萄球菌（MRSA）感染的潜在活性。
This study aimed to test the efficacy of bacteriophage-antibiotic combinations (BACs) in vitro in 24-h time-kill settings and in ex vivo simulated endocardial vegetation (SEV) pharmacokinetic/pharmacodynamic models for 96 h. BACs prevented the development of bacteriophage resistance, while some bacteriophage resistance emerged in bacteriophage-alone treatments. In addition, BACs resulted in an enhancement of bacterial eradication in SEV models. Our findings support the potential activity of BAC therapy for combating serious methicillin-resistant Staphylococcus aureus (MRSA) infections.