Incident type 2 diabetes mellitus in African American and white adults - The atherosclerosis risk in communities study
Incident type 2 diabetes mellitus in African American and white adults - The atherosclerosis risk in communities study
复制标题
DOI：
10.1001/jama.283.17.2253
复制
发表时间：
2000-05-03
影响因子：
120.7
通讯作者：
Szklo, M
中科院分区：
文献类型：
--
作者：
Brancati, FL;Kao, WHL;Szklo, M
背景虽然非裔美国人2型糖尿病的过度流行已经得到了很好的证实，少数研究比较了非裔美国人和白色人的糖尿病发病率。目的比较非裔美国人与白色成人糖尿病发病率的风险，并确定种族差异的解释因素。设计前瞻性队列研究，使用1986年至1989年收集的基线数据，从正在进行的动脉粥样硬化风险在社区（ARIC）研究中，有9年的随访。设置和参与者总共2646名非裔美国人和9461名白色成年人，年龄45至64岁，基线时没有糖尿病，从4个美国社区取样。主要结果测量2型糖尿病事件，通过医生诊断的自我报告，糖尿病药物的使用，或空腹血糖水平至少为7.0 mmol/L（126 mg/dL），比较白色和非裔美国人受试者和存在潜在的可改变的危险因素。（25.1 [95%置信区间{CI}，22.4-28.1] vs 10.4 [95% CI，9.4-11.4]），男性（23.4 [95% CI，19.9-27.2] vs 15.9 [95% CI，14.6-17.2]）是白色对照组的1.5倍（P
Context Although the excess prevalence of type 2 diabetes mellitus in African Americans is well established, few studies have compared incident diabetes in African American and white persons.Objectives To compare risk of incident diabetes in African American vs white adults and to identify explanatory factors for racial disparities.Design Prospective cohort study using baseline data collected from 1986 to 1989 from the ongoing Atherosclerosis Risk in Communities (ARIC) Study, with 9 years of follow-up.Setting and Participants A total of 2646 African American and 9461 white adults aged 45 to 64 years without diabetes at baseline, sampled from 4 US communities.Main Outcome Measures Incident type 2 diabetes, ascertained by self-report of physician diagnosis, use of diabetes medications, or fasting glucose level of at least 7.0 mmol/L (126 mg/dL), compared among white and African American subjects and by presence of potentially modifiable risk factors.Results Diabetes incidence per 1000 person-years was about 2.4-fold greater in African American women (25.1 [95% confidence interval {CI}, 22.4-28.1] vs 10.4 [95% CI, 9.4-11.4]) and about 1.5-fold greater in men (23.4 [95% CI, 19.9-27.2] vs 15.9 [95% CI, 14.6-17.2]) than in their white counterparts (P