Klinefelter’s syndrome associated with systemic lupus erythematosus and autoimmune hepatitis
Klinefelter’s syndrome associated with systemic lupus erythematosus and autoimmune hepatitis
复制标题
DOI：
10.3109/s10165-006-0511-5
复制
发表时间：
2006-10
影响因子：
2.2
通讯作者：
N. Sasaki;K. Yamauchi;R. Sato;T. Masuda;T. Sawai;H. Inoue
中科院分区：
文献类型：
--
作者：
N. Sasaki;K. Yamauchi;R. Sato;T. Masuda;T. Sawai;H. Inoue
克兰费尔特综合征 (KFS) 往往与免疫系统疾病有关。我们描述了一名 37 岁男性，他出现睾丸萎缩和体毛减少的迹象。他表现出全血细胞减少症和肝酶水平升高。染色体分析显示47XXY核型；因此，他被诊断患有KFS，患有系统性红斑狼疮和自身免疫性肝炎。高剂量甲基强的松龙和甲基睾酮治疗可改善血小板减少症和症状，表明甲基睾酮在治疗伴随免疫性疾病的低睾酮水平的 KFS 中可能具有临床益处。
Klinefelter’s syndrome (KFS) tends to be associated with immunological disorders. We describe a 37-year-old man who presented signs of testicular atrophy and decreased body hair. He showed pancytopenia and elevated levels of liver enzymes. Chromosome analysis revealed 47XXY karyotype; therefore, he was diagnosed with KFS, with systemic lupus erythematosus and autoimmune hepatitis. Treatment with a high dose of methylprednisolone and methyltestosterone improved thrombocytopenia and symptoms, suggesting that methyltestosterone may have a clinical benefit in the treatment of KFS with a low level of testosterone accompanying immunological disorders.