Single- and multistep resistance selection studies on the activity of retapamulin compared to other agents against Staphylococcus aureus and Streptococcus pyogenes
Single- and multistep resistance selection studies on the activity of retapamulin compared to other agents against Staphylococcus aureus and Streptococcus pyogenes
复制标题
DOI：
10.1128/aac.50.2.765-769.2006
复制
发表时间：
2006-02-01
影响因子：
4.9
通讯作者：
Appelbaum, PC
中科院分区：
文献类型：
--
作者：
Kosowska-Shick, K;Clark, C;Appelbaum, PC
在所有金黄色葡萄球菌菌株和产生耐药克隆的3株化脓性链球菌中，瑞帕霉素单步传代的自发突变率最低，多步传代的亲本和选择突变体mic最低。Retapamulin在化脓性葡萄球菌中具有较低的抗性选择潜力，在金黄色葡萄球菌中具有缓慢而渐进的抗性发展倾向。
Retapamulin had the lowest rate of spontaneous mutations by single-step passaging and the lowest parent and selected mutant MICs by multistep passaging among all drugs tested for all Staphylococcus aureus strains and three Streptococcus pyogenes strains which yielded resistant clones. Retapamulin has a low potential for resistance selection in S. pyogenes, with a slow and gradual propensity for resistance development in S. aureus.