Occupational hypersensitivity to metal salts, including platinum, in the secondary industry
Occupational hypersensitivity to metal salts, including platinum, in the secondary industry
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DOI：
10.1111/j.1398-9995.2004.00521.x
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发表时间：
2005-02-01
期刊：
影响因子：
12.4
通讯作者：
Picardo, M
中科院分区：
文献类型：
--
作者：
Cristaudo, A;Sera, F;Picardo, M
背景资料：接触铂族元素（PGE）-铂（Pt）、钯（Pd）、铑（Rh）和铱（Ir）-可能导致急性毒性或超敏反应，伴呼吸道症状、荨麻疹和（较不常见）接触性皮炎。我们的目的是确定的患病率和临床特点的超敏反应铂盐和其他元素的platinum group.Methods：共153名受试者在催化剂制造和回收厂进行了检查。检查包括工作接触和医疗问卷，体格检查，PGEs和其他常见的空气过敏原的皮肤点刺试验，以及PGEs的斑贴试验。用不同浓度的H-2[PtCl 6]、K-2[PtCl 4]、Na-2[PtCl 6]、IrCl 3、RhCl 3、PdCl 2及水溶液进行皮肤点刺试验和斑贴试验。（14.4%），8人对所有铂盐同时反应，7人仅对H-2[PtCl 6]反应阳性; 4例对H-2[PtCl 6]和K-2[PtCl 4]同时呈阳性反应，3例对H-2[PtCl 6]和Na-2[PtCl 6]呈阳性反应。22例中有3例对H-2[PtCl 6]和IrCl 3溶液呈阳性反应，其中2例对H-2[PtCl 6]、IrCl 3和RhCl 3溶液呈阳性反应。阳性斑贴试验反应铂盐在第2天被视为在两个153 subjects.Conclusions：本研究的结果表明，铂盐是重要的过敏原在催化剂行业和临床表现涉及呼吸系统和皮肤。六氯铂酸应被认为是最重要的盐用于皮肤点刺试验。
Background: Exposure to platinum group elements (PGEs) - platinum (Pt), palladium (Pd), rhodium (Rh) and iridium (Ir) - may cause acute toxicity or hypersensitivity with respiratory symptoms, urticaria and (less frequently) contact dermatitis. Our aim was to determine the prevalence and the clinical characteristics of hypersensitivity to platinum salts and to other elements of the platinum group.Methods: A total of 153 subjects working in a catalyst manufacturing and recycling factory were examined. The examination consisted of a work exposure and medical questionnaire, physical examination, skin prick test for PGEs and other common aeroallergens, and patch tests for PGEs. Skin prick tests and patch tests were performed with H-2[PtCl6], K-2[PtCl4], Na-2[PtCl6], IrCl3, RhCl3, PdCl2, aqueous solutions at different concentrations.Results: Positive prick test reactions to Pt-salts at various concentrations were found in 22 (14.4%) of 153 workers; eight had simultaneous reactions to all Pt-salts tested; seven had positive responses to H-2[PtCl6] only; four had simultaneous positive reactions to both H-2[PtCl6] and K-2[PtCl4]; three had positive reactions to H-2[PtCl6] and Na-2[PtCl6]. Three of 22 had positive reactions to H-2[PtCl6] and IrCl3 solutions, two of these had positive reactions to H-2[PtCl6], IrCl3 and RhCl3 solutions. Positive patch test reactions to platinum salts at day 2 were seen in two of 153 subjects.Conclusions: The results of this study demonstrate that Pt-salts are important allergens in the catalyst industry and that the clinical manifestations involve both the respiratory system and the skin. Hexachloroplatinic acid should be considered the most important salt to use for skin prick tests.