CANCER INCIDENCE AMONG FINNISH WORKERS EXPOSED TO HALOGENATED HYDROCARBONS
CANCER INCIDENCE AMONG FINNISH WORKERS EXPOSED TO HALOGENATED HYDROCARBONS
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DOI：
10.1097/00043764-199507000-00008
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发表时间：
1995-07-01
影响因子：
3.2
通讯作者：
HEMMINKI, K
中科院分区：
文献类型：
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作者：
ANTTILA, A;PUKKALA, E;HEMMINKI, K
流行病学研究和对实验动物的长期致癌研究表明，一些卤代烃是致癌的。为了调查暴露在三氯乙烯、四氯乙烯或1，1，1-三氯乙烷中是否会增加致癌风险，对2050名男性和1924名女性工人进行了1967年至1992年的癌症发病率跟踪调查。队列中的总体癌症发病率与芬兰人口相似。然而，子宫颈癌和淋巴造血组织癌的数量过多。从第一次个人测量开始，10年后出现胰腺癌和非霍奇金淋巴瘤的过剩。在那些接触三氯乙烯的人中，总的癌症发病率在20多年的随访期内增加。胃癌、肝癌、前列腺癌和淋巴造血组织的总和过多。接触1，1，1-三氯乙烷的工人患多发性骨髓瘤和神经系统癌症的风险增加。这项研究支持了三氯乙烯和其他卤代烃对肝脏和淋巴造血组织致癌的假设，特别是对非霍奇金淋巴瘤。这项研究还记录了接触溶剂的工人患上过多的胃癌、胰腺癌、子宫颈癌、前列腺癌和神经系统癌。
Epidemiologic studies and long-term carcinogenicity studies in experimental animals suggest that some halogenated hydrocarbons are carcinogenic. To investigate whether exposure to trichloroethylene, tetrachloroethylene, or 1,1,1-trichloroethane increases carcinogenic risk, a cohort of 2050 male and 1924 female workers monitored for occupational exposure to these agents was followed up for cancer incidence in 1967 to 1992. The overall cancer incidence within the cohort was similar to that of the Finnish population. There was an excess of cancers of the cervix uteri and lymphohematopoietic tissues, however. Excess of pancreatic cancer and non-Hodgkin lymphoma was seen after 10 years from the first personal measurement. Among those exposed to trichloroethylene, the overall cancer incidence was increased for a follow-up pem od of more than 20 years. There was an excess of cancers of the stomach, liver, prostate, and lymphohematopoietic tissues combined. Workers exposed to 1,1,1-trichloroethane had increased risk of multiple myeloma and cancer of the nervous system. The study provides support to the hypothesis that trichloroethylene and other halogenated hydrocarbons are carcinogenic for the liver and lymphohematopoietic tissues, especially for non-Hodgkin lymphoma. The study also documents excess of cancers of the stomach, pancreas, cervix uteri, prostate, and the nervous system among workers exposed to solvents.