Brain expression of apurinic/apyrimidinic endonuclease (APE/Ref-1) multifunctional DNA repair enzyme gene in the mouse with special reference to the suprachiasmatic nucleus
Brain expression of apurinic/apyrimidinic endonuclease (APE/Ref-1) multifunctional DNA repair enzyme gene in the mouse with special reference to the suprachiasmatic nucleus
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DOI：
10.1016/s0168-0102(03)00124-x
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发表时间：
2003-08-01
影响因子：
2.9
通讯作者：
Okamura, H
中科院分区：
文献类型：
--
作者：
Kimura, H;Dong, X;Okamura, H
多功能哺乳动物无尿嘧啶/无嘧啶核酸内切酶（APE，也称为氧化还原因子-1；Ref-1）修复氧化应激引起的DNA损伤的无基位点，并调节各种DNA结合蛋白的氧化还原状态。在这里，我们通过原位杂交检测了APE/Ref-1 m-RNA在小鼠大脑中的表达。我们在整个小鼠大脑中检测到APE/Ref-1转录本，特别是在视交叉上核（SCN）的时钟振荡神经元、海马锥体细胞、颗粒细胞和单胺能神经元中。在昼夜节律中心SCN中，APE/ref-1 mRNA转录物的水平一直很高，并且不受昼夜节律或光照的影响。(C) 2003爱思唯尔科学爱尔兰有限公司和日本神经科学学会。版权所有。
Multifunctional mammalian apurinic/apyrimidinic endonuclease (APE, also known as redox factor-1; Ref-1) repairs baseless sites of damaged DNA caused by oxidative stress and regulates the redox state of various DNA binding proteins. Here, we examined the expression of APE/Ref-1 m-RNA in the mouse brain by in situ hybridization. We detected APE/Ref-1 transcripts throughout the mouse brain particularly in the clock oscillating neurons of the suprachiasmatic nucleus (SCN), hippocampal pyramidal cells, granular cells, and in monoaminergic neurons. In the circadian center SCN, levels of APE/ref-1 mRNA transcripts were constantly high, and were not influenced by either circadian rhythms or by exposure to light. (C) 2003 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All rights reserved.