Human Immunodeficiency Virus Co-Infection Increases Placental Parasite Density and Transplacental Malaria Transmission in Western Kenya
Human Immunodeficiency Virus Co-Infection Increases Placental Parasite Density and Transplacental Malaria Transmission in Western Kenya
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DOI：
10.4269/ajtmh.2009.80.119
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发表时间：
2009-01-01
影响因子：
3.3
通讯作者：
Kain, Kevin C.
中科院分区：
文献类型：
--
作者：
Perrault, Steven D.;Hajek, Jan;Kain, Kevin C.
Plasmodium falciparum malaria and human immunodeficiency virus (HIV)-1 adversely interact in the context of pregnancy. however little is known regarding the influence of co-infection oil the risk of congenital malaria. We aimed to determine the prevalence of placental and congenital malaria and impact of HIV co-infection oil transplacental malaria transmission in 157 parturient women and their infants by microscopy and by quantitative real-time polymerase chain reaction (PCR) in western Kenya. The prevalence of Placental and cord blood infections were 17.2%, an 0% by microscopy, and 33.1% and 10.8% by PCR. HIV co-infection w as associated with a significant increase in placental parasite density (P < 0.05). Cord blood malaria prevalence was increased in co-infected women (odds ratio [OR] = 5.42: 95% confidence interval [CI] = 1.90-15.47) and correlated with placental parasite density (OR = 2.57: 95% CI = 1.80-3.67). A 1-log increase in placental monocyte count was associated with increased risk of congenital infection (P = 0.001) (OR 48.15: 95% CI = 4.59-505.50). The HIV co-infected women have a significantly increased burden of placental malaria that increases the risk of congenital infection.
