Magnetic resonance imaging of self-assembled biomaterial scaffolds
Magnetic resonance imaging of self-assembled biomaterial scaffolds
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DOI：
10.1021/bc050153h
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发表时间：
2005-11-01
影响因子：
4.7
通讯作者：
Meade, TJ
中科院分区：
文献类型：
--
作者：
Bull, SR;Guler, MO;Meade, TJ
当前对组织工程和药物递送应用的生物材料的兴趣促使研究对自组装肽两亲物（PAS）的研究。由自组装PA形成的纳米纤维网络可以用作生物材料支架，并通过掺入肽 - 发po的优势。对材料进行非侵入性的成像将提供有关其体内命运的信息。我们在这里报告形成纳米纤维的自组装肽对比剂（PACA）的合成和体外MR图像。使用PA的0.1 mM GD（III）偶联物在400 MHz时，我们观察到了对照凝胶的T-1三倍。将PA衍生物掺入了各种表位溶液中，胶凝产生了MRI成像的均匀生物材料。
Current interest in biomaterials for tissue engineering and drug delivery applications have spurred research into self-assembling peptide amphiphiles (PAs). Nanofiber networks formed from self-assembling PAs can be used as biomaterial scaffolds with the advantage of specificity by the incorporation of peptide-epitopes. Imaging the materials noninvasively will give information as to their fate in vivo. We report here the synthesis and in vitro MR images of self-assembling peptide amphiphile contrast agents (PACAs) that form nanofibers. At 400 MHz using a 0.1 mM Gd(III) conjugate of the PA we observed a T-1 three times that of a control gel. The PA derivative was doped into various epitope bearing PA solutions and upon gelling resulted in a homogeneous biomaterial as imaged by MRI.