Voxel-based morphometry detects cortical atrophy in the Parkinson variant of multiple system atrophy
Voxel-based morphometry detects cortical atrophy in the Parkinson variant of multiple system atrophy
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DOI：
10.1002/mds.10502
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发表时间：
2003-10-01
影响因子：
8.6
通讯作者：
Wenning, GK
中科院分区：
文献类型：
--
作者：
Brenneis, C;Seppi, K;Wenning, GK
为了确定帕金森综合征脑萎缩的磁共振成像（MRI）模式，我们应用基于体素的形态测定法（VBM）对12例可能患有多系统萎缩-帕金森变异型（MSA-P）和12例帕金森病患者的T-1加权脑体积的分段灰质、白色物质和脑脊液室进行了研究，并将其与12例年龄匹配的正常对照组进行了比较。与对照组相比，在MSA-P患者中观察到皮质萎缩模式，在双侧初级感觉运动皮质、双侧辅助运动区、右侧运动前皮质、双侧前额叶皮质（额中回）和双侧岛叶皮质中存在显著的体积损失集群;双侧尾状核和壳核以及中脑中出现皮质下萎缩。此外，在侧脑室，第三脑室，中脑周围和小脑延髓腔中发现脑脊液室扩大。PD患者仅左侧尾状核萎缩，左侧脑室扩大。将MSA-P与PD患者进行比较，MSA-P显示出与对照组相似的皮质萎缩模式。我们的结论是，VBM显示选择性皮质萎缩的患者与MSA-P影响初级和高级运动区，以及前额叶和岛叶皮质。需要进一步的研究来确定MSA-P中皮质萎缩的临床和/或亚临床相关性。（C）2003运动障碍学会。
To determine magnetic resonance imaging (MRI) patterns of brain atrophy in parkinsonian syndromes, we applied voxel-based morphometry (VBM) to segmented gray matter, white matter, and cerebrospinal fluid compartments of T-1-weighted brain volumes of 12 patients with probable multiple system atrophy-parkinson variant (MSA-P) and 12 Parkinson's disease patients, comparing them with 12 normal controls matched for age. In comparison to controls, a cortical atrophy pattern was observed in MSA-P patients with significant clusters of volume loss in primary sensorimotor cortices bilateral, supplementary motor areas bilateral, right premotor cortex, prefrontal cortex bilateral (middle frontal gyri) and insular cortices bilateral; subcortical atrophy occurred bilaterally in caudate nuclei and putamen as well as in the midbrain. Furthermore, an enlargement of the cerebrospinal fluid compartment was found in the lateral ventricles, third ventricle, perimesencephalic and cerebellomedullar cavities. In PD patients, significant atrophy only occurred in left caudate head with enlargement of left lateral ventricle. Comparing MSA-P to PD patients, MSA-P showed a similar cortical pattern of atrophy as compared to controls. We conclude that VBM reveals selective cortical atrophy in patients with MSA-P affecting primary and higher order motor areas as well as prefrontal and insular cortices. Further studies are required to determine clinical and/or subclinical correlates of cortical atrophy in MSA-P. (C) 2003 Movement Disorder Society.