Total synthesis of aristolactams via a one-pot suzuki-miyaura coupling/aldol condensation cascade reaction
Total synthesis of aristolactams via a one-pot suzuki-miyaura coupling/aldol condensation cascade reaction
复制标题
DOI：
10.1021/ol801291k
复制
发表时间：
2008-08-21
期刊：
影响因子：
5.2
通讯作者：
Heo, Jung-Nyoung
中科院分区：
文献类型：
--
作者：
Kim, Joa Kyum;Kim, Young Ha;Heo, Jung-Nyoung
以异吲哚-1- 1与2-甲酰苯基硼酸为原料，采用Suzuki-Miyaura偶联/醛醇缩合级联反应，直接一锅法合成了菲内酰胺。该方法可有效生产多种天然马兜铃内酰胺，如马兜铃内酰胺BII（头孢烷酮B）、马兜铃内酰胺BIII、马兜铃内酰胺FI（胡椒内酰胺a）、n -甲基胡椒内酰胺a和蛇耳内酰胺。
A direct one-pot synthesis of phenanthrene lactams, which employs a Suzuki-Miyaura coupling/aldol condensation cascade reaction of isoindolin-1-one with 2-formyl phenyl boronic acid, has been developed. The approach is used to efficiently produce a number of natural aristolactams, such as aristolactam BII (cepharanone B), aristolactam BIII, aristolactam FI (piperolactam A), N-methyl piperolactam A, and sauristolactam.