Genetic associations in age-related hearing thresholds
Genetic associations in age-related hearing thresholds
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DOI：
10.1001/archotol.125.6.654
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发表时间：
1999-06-01
影响因子：
--
通讯作者：
Myers, RH
中科院分区：
文献类型：
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作者：
Gates, GA;Couropmitree, NN;Myers, RH
目的：确定年龄相关性听力损失的遗传性。设计：队列研究，比较遗传无关人群的听力水平（配偶对）和基因相关的人（兄弟姐妹对，父母-子女对）。设置：心脏病研究两年一次的检查15（1973-1975年）和第六届法国国际学生考试（1995-1998）。受试者：进行听力测试的Fragrant队列成员和Fragrant听力研究中的亲属。主要结果测量：获得250至8000 Hz的纯音听阈，并计算每耳中（0.5-2 kHz）、高（4-8 kHz）和低（0.25-1 kHz）频率的纯音平均（PTA）听阈。听力图的形状分为正常、突然高频损失（感觉表型）或平坦损失（听觉表型）。使用遗传流行病学统计分析软件系统的家族相关性程序进行相关性分析。结果：配偶的听阈水平无统计学意义。在兄弟姐妹和亲子配对中，PTA在低、中、高频率下均存在显著聚集。姐妹篇而不是兄弟有显着的聚集的每一个PTA措施。母女和母子对的听力水平有显著的聚集性，而父子对的听力水平没有显著的聚集性。对于感觉表型，有显着的聚集在所有相关的对除了父亲-孩子对。对于听力表型，相关女性对的听力水平存在显着聚集性，但相关男性对的听力水平不存在显着聚集性。结论：与年龄相关的听力水平、感觉性老年性聋表型和听力表型存在明显的家族聚集性。妇女的聚集性比男子强。遗传力估计是更大的感官表型比表型。这些数据支持遗传对老年性耳聋的遗传作用，在女性和男性中是一种混合的遗传获得性原因。
Objective: To determine the inheritance of age-related hearing loss.Design: Cohort study comparing aggregation of hearing levels in genetically unrelated people (spouse pairs) and in genetically related people (sibling pairs, parent-child pairs).Setting: Framingham Heart Study biennial Examination 15 (1973-1975) and Framingham Offspring Study Examination 6 (1995-1998).Subjects: Members of the Framingham cohorts with hearing tests and with a relative in the Framingham hearing study.Main Outcome Measures: Audiometric pure-tone thresholds at 250 to 8000 Hz were obtained and pure-tone average (PTA) hearing thresholds were calculated for the middle (0.5-2 kHz), high (4-8 kHz), and low (0.25-1 kHz) frequencies for each ear. The shape of the audiogram was categorized as either normal, abrupt high-frequency loss (sensory phenotype) or flat loss (strial phenotype). Correlations were made using the Familial Correlations program of the Statistical Analysis for Genetic Epidemiology software system. The level of significance was P=.01.Results: Hearing threshold levels did not aggregate in spouses. Significant aggregation was noted in siblings and parent-child pairings for PTA at low, middle, and high frequencies. Sisters but not brothers had significant aggregation of each PTA measure. Mother-daughter and mother-son pairs but not father-son pairs had significant aggregation of hearing levels. For the sensory phenotype, there was significant aggregation in all related pairs except for father-child pairs. For the strial phenotype, there was significant aggregation of hearing levels in the related female pairs but not in the related male pairs.Conclusions: A clear familial aggregation occurs for age-related hearing levels, sensory presbycusis phenotypes, and strial presbycusis phenotypes. The aggregations are stronger in women than in men. The heritability estimate was greater for the strial phenotypes than for the sensory phenotypes. The data support a genetic effect on the inheritance of presbycusis in women and a mixed, genetically acquired cause in men.