Ageing, physical activity and mortality-a 42-year follow-up study
Ageing, physical activity and mortality-a 42-year follow-up study
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DOI：
10.1093/ije/dyr205
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发表时间：
2012-04-01
影响因子：
7.7
通讯作者：
Wyller, Torgeir B.
中科院分区：
文献类型：
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作者：
Gulsvik, Anne K.;Thelle, Dag S.;Wyller, Torgeir B.
背景：在一般人群中，体力活动（PA）与死亡率呈负相关。我们希望量化自我报告的PA与各种原因死亡率、缺血性心脏病（IHD）和中风的关系，并将其与不同年龄段的其他已知危险因素进行比较。方法卑尔根临床血压调查于1965-71年对6811名挪威男性和女性进行了随访，随访至2005-07年。分别计算老年人（50 ~ 65岁）、中年人（45 ~ 64岁）和年轻人（22 ~ 44岁）的Cox比例风险回归比（HR）和人口归因分数（PAF）。我们通过渐进式综合调整和亚组分析（排除早期随访死亡、自我报告疾病的参与者和由于疾病导致其pa水平先前基线改变的参与者）来最小化混淆和偏倚。结果与高pa水平相关的全因死亡率、IHD和卒中的HR[95%可信区间（CI）]分别为0.63（0.56-0.71）、0.66（0.52-0.83）和0.66(0.47-0.93)（参考：未参加任何列出的活动，根据年龄和性别进行调整）。无/低活动（参考：任何活动）的PAF （95% CI）在所有年龄组中都是一致的，从年轻人的7.3%（3.4-11.4）到老年人的9.1%（3.6-15.3）不等。吸烟和高s-胆固醇的PAF随年龄增长而下降[吸烟从19.9%（15.3-24.7）降至1.5% (-1.3 - 6.2)，s-胆固醇从11.5%（5.6-17.5）降至-9.5%(-18.1 -0.7)]，而高血压的PAF从5.3%（2.1-9.1）上升至18.9%（8.3-28.4）。结论传统危险因素的相对重要性在不同年龄组之间有所不同，但体育活动是所有年龄组的主要健康促进因素，特别是在老龄化人口中应予以鼓励。
Background Physical activity (PA) is inversely associated with mortality in the general population. We wanted to quantify the association of self-reported PA with mortality from all causes, ischaemic heart disease (IHD) and stroke, and compare it with other known risk factors in different age segments.Methods The Bergen Clinical Blood Pressure Survey examined a sample of 6811 Norwegian men and women in 1965-71 with follow-up until 2005-07. Cox proportional hazard regression ratio (HR) and population attributable fraction (PAF) were calculated for the old (> 65), middle-aged (45-64) and young adults (22-44), respectively. We minimized confounding and bias by progressive comprehensive adjustments and subgroup-analyses (excluding early follow-up deaths, participants with self-reported disease and participants with changes in their PA-level prior baseline due to disease).Results The HR [95% confidence interval (CI)] associated with a high PA-level was 0.63(0.56-0.71), 0.66(0.52-0.83) and 0.66(0.47-0.93) for mortality from all causes, IHD and stroke, respectively (reference: no participation in any of the listed activities, adjusted for age and gender). PAF (95% CI) of no/low activity (reference: any activity) was consistent across all age groups, varying from 7.3% (3.4-11.4) in the young adults to 9.1% (3.6-15.3) in the old. PAF of smoking and high s-cholesterol declined with increasing age [smoking from 19.9% (15.3-24.7) to 1.5% (-1.3 to 6.2) and s-cholesterol from 11.5% (5.6-17.5) to -9.5% (-18.1 to -0.7)], whereas PAF of hypertension increased from 5.3% (2.1-9.1) to 18.9% (8.3-28.4).Conclusion The relative importance of traditional risk factors varies between the age groups, but physical activity is a major health promoting factor across all age segments and should be encouraged particularly in an ageing population.