Temporal variability of organophosphate insecticide metabolites over one year in Chinese adults.
Temporal variability of organophosphate insecticide metabolites over one year in Chinese adults.
复制标题
DOI：
10.1016/j.scitotenv.2021.149041
复制
发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Xuan Lin;Zhe Zhang;Binbin Wu;Jing Liu
中科院分区：
文献类型：
--
作者：
Xuan Lin;Zhe Zhang;Binbin Wu;Jing Liu
有机磷杀虫剂是一类生物半衰期短的非持久性污染物，在世界范围内广泛使用。大多数OP杀虫剂在人体内迅速代谢为六种磷酸二烷基酯代谢物（DAP），其中尿浓度通常用于评估OP杀虫剂暴露。在这项研究中，为了了解OP杀虫剂代谢物的单次测量在代表真实长期平均暴露方面的可靠性，我们调查了114名18-30岁中国成年人一年内尿DAP的时间变异性。6种DAP代谢产物的检出率均超过98%。DAPs的组内相关系数（ICC）表明，在一周、一个月或一年内的现场尿液样本中，重复性较差（ICC <0.4）至一般（ICC = 0.4-0.75）。对数转换的DAP代谢物要求每个受试者2-12个点尿样，以提供几个月或一年内OP杀虫剂暴露的可靠估计。用一个、两个或三个尿样预测受试者一年平均OP杀虫剂暴露量的灵敏度和特异性分别为0.25至0.991、0.491至0.966。我们建议使用对数转换的DAP评估一年OP杀虫剂暴露的至少3个现场尿样。本研究为在生物监测和流行病学研究中对有机磷杀虫剂的长期暴露进行合理评价提供了参考。
Organophosphate (OP) insecticides widely used worldwide are a class of non-persistent pollutants with a short biological half-life. Most OP insecticides are rapidly metabolized in the human body to six dialkyl phosphate metabolites (DAPs), of which urinary concentrations are usually used to assess OP insecticide exposures. In this study, to understand the reliability of a single measurement of OP insecticide metabolites in representing a true longer-term average exposure, we investigated the temporal variability of urinary DAPs over one year in 114 Chinese adults aged 18–30. The detection rates for all six DAP metabolites exceeded 98%. The intraclass correlation coefficients (ICCs) of DAPs indicated poor (ICC < 0.4) to fair (ICC = 0.4–0.75) reproducibility in spot urine samples over one week, month, or year. Log-transformed DAP metabolites requested 2–12 spot urine samples per subject to offer a reliable estimate of OP insecticide exposures over several months or one year. The sensitivity and specificity for predicting subjects with the one-year average OP insecticide exposure in the highest tertile with one, two, or three urine samples varied from 0.25 to 0.991, 0.491 to 0.966, respectively. We recommend at least 3 spot urine samples for the assessment of one-year OP insecticide exposure by using log-transformed DAPs. This study offers a reference for an appropriate evaluation of a relatively long-period exposure to OP insecticides in biomonitoring and epidemiological studies.