Blood-based biomarkers for Parkinson's disease.
Blood-based biomarkers for Parkinson's disease.
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DOI：
10.1016/s1353-8020(13)70025-7
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发表时间：
2014-01
影响因子：
4.1
通讯作者：
Chen-Plotkin, Alice
中科院分区：
文献类型：
--
作者：
Chahine, Lama M;Stern, Matthew B;Chen-Plotkin, Alice
目前迫切需要生物标志物来诊断帕金森病（PD），评估疾病严重程度和预测病程。各种类型的生物样本是用于识别生物标志物的潜在候选者-在此定义为生理或病理生理状态的替代指标-但血液具有微创获取的优势。然而，识别血液中的生物标志物存在一些挑战。在其他疾病或其他类型的生物液体中鉴定的几种候选生物标志物正在被追求作为PD中的血液生物标志物。此外，使用代谢组学、蛋白质组学和基因表达谱分析等技术正在进行无偏见的发现。在这篇综述中，我们总结了这些技术，并讨论了PD中基于血液的生物标志物发现的挑战和成功。讨论的基于血液的生物标志物包括α-突触核蛋白、DJ-1、尿酸、表皮生长因子、载脂蛋白-A1和外周炎症标志物。
There is a pressing need for biomarkers to diagnose Parkinson’s disease (PD), assess disease severity, and prognosticate course. Various types of biologic specimens are potential candidates for identifying biomarkers – defined here as surrogate indicators of physiological or pathophysiological states – but blood has the advantage of being minimally invasive to obtain. There are, however, several challenges to identifying biomarkers in blood. Several candidate biomarkers identified in other diseases or in other types of biological fluids are being pursued as blood-based biomarkers in PD. In addition, unbiased discovery is underway using techniques including metabolomics, proteomics, and gene expression profiling. In this review, we summarize these techniques and discuss the challenges and successes of blood-based biomarker discovery in PD. Blood-based biomarkers that are discussed include α-synuclein, DJ-1, uric acid, epidermal growth factor, apolipoprotein-A1, and peripheral inflammatory markers.