Serum complement C4a and its relation to liver fibrosis in children with chronic hepatitis C
Serum complement C4a and its relation to liver fibrosis in children with chronic hepatitis C
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DOI：
10.4254/wjh.v5.i8.445
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发表时间：
2013-08-27
影响因子：
2.4
通讯作者：
Sira, Mostafa M.
中科院分区：
文献类型：
--
作者：
Behairy, Behairy E.;El-Mashad, Ghada M.;Sira, Mostafa M.
AIM: To evaluate serum complement C4a and its relation to liver fibrosis in children with chronic hepatitis C virus (HCV) infection.METHODS: The study included 30 children with chronic HCV infection before receiving antiviral therapy. Chronic HCV infection was defined by positive anti-HCV, a positive polymerase chain reaction for HCV-RNA for more than 6 mo with absence of any associated liver disease. A second group of 30 age-and sex-matched healthy children served as controls. Serum C4a levels were measured by enzyme-linked immunosorbent assay. Liver fibrosis stage and inflammatory grade were assessed using Ishak scoring system. Serum C4a levels were compared according to different clinical, laboratory and histopathological parameters. Statistical significance for quantitative data was tested by MannWhitney U non-parametric tests. For qualitative data, significance between groups was tested by. 2 test. Correlation was tested by Spearman's test. Results were considered significant if P value
