EFFECT OF HYPOTHERMIA ON OXYGEN CONSUMPTION AND ENERGY UTILIZATION OF HEART
EFFECT OF HYPOTHERMIA ON OXYGEN CONSUMPTION AND ENERGY UTILIZATION OF HEART
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DOI：
10.1161/01.res.4.5.523
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发表时间：
1956-01-01
影响因子：
20.1
通讯作者：
BADEER, H
中科院分区：
文献类型：
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作者：
BADEER, H
心肌耗氧量是通过直接菲克法测定狗心肺标本中的心肌耗氧量，该法是根据罗巴德测量总冠脉流量的技术进行修改的。采用Van Slyke测压仪测定肺动脉中动脉血和冠状混合静脉血的O2含量。在10个经受低温的实验中，其中心脏做功保持恒定在约0.50kg-M./分钟，心肌O 2 摄取在36℃和26℃之间呈指数下降，Q10为1.83。在这些条件下，冠状动脉流量保持不变，当温度达到26℃时，A-V O2差值下降，O2吸收减少。机械效率从4.7%增加到8.9%。复温后（4 次实验），心肌吸氧量和机械效率恢复到预冷值。结论是低温不会干扰心肌对有氧能量的利用。
Myocardial O2 consumption was determined by direct Fick method in the dog heart-lung preparation modified according to Rodbard''s technique to measure the total coronary flow. O2 content of arterial and coronary mixed venous blood in pulmonary artery was determined by Van Slyke manometric apparatus. In 10 experiments subjected to hypothermia during which cardiac work was kept constant at about 0.50 kg-M./minute, myocardial O2 uptake declined exponentially between 36 and 26 C, with a QlO of 1.83. Under these conditions coronary flow remained unchanged, A-V O2 difference dropped and O2 uptake diminished when temperature reached 26 C. Mechanical efficiency increased from 4.7 to 8.9%. Upon rewarming (4 experiments), myocardial O2 uptake and mechanical efficiency returned to precooling values. It is concluded that hypothermia does not interfere with the utilization of aerobic energy by heart muscle.