Suboptimal Viral Suppression Rates Among HIV-Infected Children in Low- and Middle-Income Countries: A Meta-analysis
Suboptimal Viral Suppression Rates Among HIV-Infected Children in Low- and Middle-Income Countries: A Meta-analysis
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DOI：
10.1093/cid/ciw645
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发表时间：
2016-12-15
影响因子：
11.8
通讯作者：
Sigaloff, Kim C. E.
中科院分区：
文献类型：
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作者：
Boerma, Ragna S.;Boender, T. Sonia;Sigaloff, Kim C. E.
背景90-90-90的目标是在90%接受抗逆转录病毒治疗（ART）的人类免疫缺陷病毒（HIV）感染者中实现病毒抑制，这在儿童中尤其具有挑战性。全球对低收入和中等收入国家（LMIC）儿童病毒抑制的估计缺乏。我们检索了随机对照试验和观察性研究，并使用随机效应荟萃分析了3个时间段内开始接受ART的儿童的病毒抑制率：早期（2000-2005），中期（2006-2009）和当前（2010年及以后）。72项研究，报告了51347名儿童（年龄
Background. The 90-90-90 goal to achieve viral suppression in 90% of all human immunodeficiency virus (HIV)-infected people on antiretroviral treatment (ART) is especially challenging in children. Global estimates of viral suppression among children in low-and middle-income countries (LMICs) are lacking.Methods. We searched for randomized controlled trials and observational studies and analyzed viral suppression rates among children started on ART during 3 time periods: early (2000-2005), intermediate (2006-2009), and current (2010 and later), using random effects meta-analysis.Results. Seventy-two studies, reporting on 51 347 children (aged