Calcification in Major Vessel Beds Relates to Vascular Brain Disease
Calcification in Major Vessel Beds Relates to Vascular Brain Disease
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DOI：
10.1161/atvbaha.111.232728
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发表时间：
2011-10-01
影响因子：
8.7
通讯作者：
Vernooij, Meike W.
中科院分区：
文献类型：
--
作者：
Bos, Daniel;Ikram, M. Arfan;Vernooij, Meike W.
动脉粥样硬化斑块中的钙化是一种新的动脉粥样硬化标志物，与心血管疾病有关。然而，其与脑血管疾病的关系尚未得到广泛研究。我们调查了钙化在各种血管床外的大脑和影像学标记的血管性brain diseases.Methods和Results-A共885社区居住的人（平均年龄，66.7岁）进行了计算机断层扫描的冠状动脉，主动脉弓，颅外和颅内颈动脉，以评估动脉钙化。进行脑磁共振成像扫描以评估脑梗死、微出血和白色病变（WML）。每个血管床的钙化与脑梗死的存在和较大的WML体积相关。颅内颈动脉钙化和WML体积之间以及颅外颈动脉钙化和梗死之间存在最显著的相关性。调整心血管危险因素或超声颈动脉斑块评分并没有改变这些结果。钙化和脑微bleeds.Conclusion-Arterial钙化在主要血管床与血管性脑疾病的磁共振成像。最值得注意的是，较大的颅内颈动脉钙化负荷与较大的WML体积相关，较大的颅外颈动脉钙化负荷与脑梗死的存在相关，与超声颈动脉斑块评分无关。这表明动脉粥样硬化斑块的钙化除了斑块的存在外还产生其他信息，为血管性脑疾病的病因学提供了新的见解。（Arterioscler Thromb Vasc Biol.2011;31：2331-2337.）
Objective-Calcification in atherosclerotic plaques is a novel marker of atherosclerosis and is related to cardiovascular disease. However, its relationship with cerebrovascular disease has not been investigated extensively. We investigated the relationship between calcification in various vessel beds outside the brain and imaging markers of vascular brain disease.Methods and Results-A total of 885 community-dwelling people (mean age, 66.7 years) underwent computed tomography of the coronary arteries, aortic arch, and extracranial and intracranial carotid arteries to assess arterial calcification. Brain magnetic resonance imaging scans were performed to assess cerebral infarcts, microbleeds, and white matter lesions (WMLs). Calcification in each vessel bed was associated with presence of cerebral infarcts and with larger WML volume. The most prominent associations were found between intracranial carotid calcification and WML volume and between extracranial carotid calcification and infarcts. Adjustment for cardiovascular risk factors or ultrasound carotid plaque scores did not change these results. No associations were found between calcification and cerebral microbleeds.Conclusion-Arterial calcification in major vessel beds is associated with vascular brain disease on magnetic resonance imaging. Most notably, larger intracranial carotid calcification load relates to larger WML volumes, and larger extracranial carotid calcification load relates to the presence of cerebral infarcts, independently of ultrasound carotid plaque score. This suggests that calcification of atherosclerotic plaque yields other information in addition to merely the presence of plaques, providing novel insights into the etiology of vascular brain disease. (Arterioscler Thromb Vasc Biol. 2011;31:2331-2337.)