Sleep-disordered breathing symptoms are associated with poorer cognitive function in 5-year-old children
Sleep-disordered breathing symptoms are associated with poorer cognitive function in 5-year-old children
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DOI：
10.1016/j.jpeds.2004.05.039
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发表时间：
2004-10-01
影响因子：
5.1
通讯作者：
Lesko, SM
中科院分区：
文献类型：
--
作者：
Gottlieb, DJ;Chase, C;Lesko, SM
目的探讨儿童睡眠呼吸障碍(SDB)症状与神经认知功能的关系。研究设计以205名5岁儿童为研究对象。父母填写的问卷被用来确定SDB的症状，定义为频繁打呼、睡眠中呼吸嘈杂或响亮，或目击睡眠呼吸暂停。85%的儿童可获得多导睡眠图(PSG)数据。标准化的神经认知测试是由一名训练有素的心理测量师进行的，他们并不知道儿童的SDB状况。结果有SDB症状的儿童在执行功能测试中的得分显著低于无SDB症状的儿童(在Net SY注意/执行核心领域得分分别为95.5和99.9，P=0.02；修订后的韦氏学前和小学智力量表(WPPSI-R)，记忆(96.8vs 103.0，P=0.02)和一般智力(WPPSI-R全量智商(105.9 vs 111.7，P=0.02)。在计算机化的连续操作任务上没有显著差异。当有阻塞性睡眠呼吸暂停(OSA)的PSG证据的儿童被排除在分析之外时，这些发现仍然存在。结论即使在没有OSA的情况下，5岁儿童的SDB症状也与执行功能和记忆技能以及一般智力下降有关。
Objective To assess the relation of sleep-disordered breathing (SDB) symptoms in children to neurocognitive function.Study design A cross-sectional, population-based study of 205 5-year-old children. A parent-completed questionnaire was used to ascertain SDB symptoms, defined as frequent snoring, loud or noisy breathing during sleep, or witnessed sleep apnea. Polysomnography (PSG) data were available in 85% of children. Standardized neurocognitive tests were administered by a trained psychometrist unaware of the children's SDB status. Children with (n = 61) and without SDB symptoms were compared using analysis of variance to adjust for demographic and respiratory health variables.Results Children with SDB symptoms scored significantly lower than those without SDB symptoms on tests of executive function (95.5 vs 99.9 on NEPSY Attention/Executive Core Domain, P = .02; 10.4 vs 11.2 on Wechsler Preschool and Primary Scale of Intelligence, Revised [WPPSI-R] Animal Pegs test, P = .03), memory (96.8 vs 103.0 on NEPSY Memory Domain, P = .02), and general intellectual ability (105.9 vs 111.7 on WPPSI-R Full Scale IQ, P = .02). There were no significant differences on a computerized continuous performance task. These findings persisted when children with PSG evidence of obstructive sleep apnea (OSA) were excluded from analysis.Conclusion Even in the absence of OSA, SDB symptoms are associated with poorer executive function and memory skills and lower general intelligence in 5-year-old children.