Enhanced oxygen delivery induced by perfluorocarbon emulsions in capillary tube oxygenators.
Enhanced oxygen delivery induced by perfluorocarbon emulsions in capillary tube oxygenators.
复制标题
毛细管充氧器中的全氟化碳乳液增强了氧气输送。
DOI：
10.1097/00002480-199407000-00077
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Goldstick,TK
中科院分区：
文献类型：
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作者：
Vaslef,SN;Goldstick,TK
先前的研究表明，新一代全氟化碳（PFC）乳剂增加了猫视网膜组织PO2的程度，但不能用低剂量1 g PFC/kg体重输注后动脉O2含量的微小增加来解释。PFC输注后组织水平O2输送的增加似乎是由微循环的局部作用引起的。作者在体外稳态闭环回路中研究了这种效应，该回路由两种类型的毛细血管充氧器、脱氧器、充满抗凝牛血或生理盐水的储液袋（对照组）和辊泵组成，以观察在血流量为3 l/min时，PFC的添加是否会对毛细血管膜充氧器的PO2差（[DELTA] PO2）产生影响。全氟化碳分三次添加，每次添加约0.7 vol%的全氟化碳。在每次添加前后测量氧合器上的[DELTA] PO2。两种氧合器血液中[DELTA] PO2的平均增加百分比分别为19.2+/-8%（平均+/-SD， n= 6， P= 0.002）和9.9+/-4%(n= 3， P= 0.05)，而盐水中[DELTA] PO2的平均变化百分比为-4.9+/-2%（n= 2， P= 0.2）。氧合器的入口PO2s仅轻微增加。作者得出结论，在毛细血管模型中注射PFC后，O2的输送明显增强。PFC颗粒的近壁过量可能是该模型中O2扩散增强的原因。
Previous studies showed that a new generation of perfluorocarbon (PFC) emulsions increased tissue PO2 in the cat retina to a degree that could not be explained by the small increase in arterial O2 content seen after the infusion of low doses of 1 g PFC/kg body weight. It seems that increased O2 delivery at the tissue level after PFC infusion is caused by a local effect in the microcirculation. The authors studied this effect in vitro at steady state in a closed loop circuit, consisting of one of two types of capillary tube oxygenators, deoxygenator (s), a reservoir bag filled with anticoagulated bovine blood or saline (control), and a roller pump, to see if the addition of PFC would have an effect on the PO2 difference ([DELTA] PO2) across the capillary tube membrane oxygenator at a blood flow rate of 3 l/min. Perfluorocarbon was added in three incremental doses, each giving about 0.7 vol% of PFC. The [DELTA] PO2 across the oxygenator was measured before and after each dose. The mean percent increases in [DELTA] PO2 in blood for two types of oxygenators were 19.2+/-8%(mean+/-SD, n= 6, P= 0.002) and 9.9+/-4%(n= 3, P= 0.05), respectively, whereas the mean percent change in [DELTA] PO2 in saline was-4.9+/-2%(n= 2, P= 0.2). Inlet PO2s to the oxygenator were only minimally increased. The authors conclude that O2 delivery was significantly enhanced after injection of PFC in blood in this capillary tube model. A near wall excess of PFC particles may account for the augmentation of O2 diffusion in this model.