Noninvasive Diagnosis of Ischemia-Causing Coronary Stenosis Using CT Angiography Diagnostic Value of Transluminal Attenuation Gradient and Fractional Flow Reserve Computed From Coronary CT Angiography Compared to Invasively Measured Fractional Flow Reserve
Noninvasive Diagnosis of Ischemia-Causing Coronary Stenosis Using CT Angiography Diagnostic Value of Transluminal Attenuation Gradient and Fractional Flow Reserve Computed From Coronary CT Angiography Compared to Invasively Measured Fractional Flow Reserve
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DOI：
10.1016/j.jcmg.2012.09.002
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发表时间：
2012-11-01
影响因子：
14
通讯作者：
Park, Young-Bae
中科院分区：
文献类型：
--
作者：
Yoon, Yeonyee E.;Choi, Jin-Ho;Park, Young-Bae
目的：本研究的目的是比较冠状动脉计算机断层血管造影（CCTA）衍生的计算分数血流储备（FFRCT）和腔内衰减梯度（TAG）在诊断病变特异性缺血中的诊断性能。虽然CCTA通常用于检测冠状动脉疾病（CAD），但它不能可靠地评估CAD的功能意义。开发了基于CCTA的新技术，以整合CAD的解剖和功能评估；然而，这些方法的诊断性能从未被比较过。方法纳入53例连续行CCTA和冠状动脉造影并测量FFR的患者。独立核心实验室通过CCTA、TAG和FFRCT确定CAD严重程度。TAG定义为腔内辐射衰减与离腔长度之间的线性回归系数；FFRCT采用计算流体力学技术从CCTA数据中计算。结果82条血管中有创性FFR （FFR）导致32个病变（39%）缺血
OBJECTIVES The aim of this study was to compare the diagnostic performance of coronary computed tomography angiography (CCTA)-derived computed fractional flow reserve (FFRCT) and transluminal attenuation gradient (TAG) for the diagnosis of lesion-specific ischemia.BACKGROUND Although CCTA is commonly used to detect coronary artery disease (CAD), it cannot reliably assess the functional significance of CAD. Novel technologies based on CCTA were developed to integrate anatomical and functional assessment of CAD; however, the diagnostic performance of these methods has never been compared.METHODS Fifty-three consecutive patients who underwent CCTA and coronary angiography with FFR measurement were included. Independent core laboratories determined CAD severity by CCTA, TAG, and FFRCT. The TAG was defined as the linear regression coefficient between intraluminal radiological attenuation and length from the ostium; FFRCT was computed from CCTA data using computational fluid dynamics technology.RESULTS Among 82 vessels, 32 lesions (39%) had ischemia by invasive FFR (FFR