Distribution of progesterone receptor immunoreactivity in the fetal and neonatal rat forebrain
Distribution of progesterone receptor immunoreactivity in the fetal and neonatal rat forebrain
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DOI：
10.1002/cne.21427
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发表时间：
2007-09-01
影响因子：
2.5
通讯作者：
Wagner, Christine K.
中科院分区：
文献类型：
--
作者：
Quadros, Princy S.;Pfau, Jennifer L.;Wagner, Christine K.
类固醇激素在神经发育中起着重要作用。除了胎儿和新生儿来源的雄激素和雌激素外，发育中的大脑也可能暴露于孕酮。在这方面，确定前脑核是敏感的孕酮在神经发育过程中可能阐明孕激素对大脑发育的影响。本研究采用免疫细胞化学方法，观察了孕激素受体（PR）在胚胎17天至出生后28天大鼠前脑中的表达分布。结果表明，PR在发育中的大脑中的表达是广泛的，存在于许多前脑核团，但短暂的，在P28的PR表达在大多数核团中不存在。显示最高水平的PR-免疫反应（PRIR）的区域被发现在视前核和下丘脑核，包括内侧视前核，前腹侧室周，弓状核和腹内侧核。PRir在边缘区中等丰富，特别是在杏仁核、终纹床核和海马体的分区中。脉络丛和新皮质是表现出相对丰富的PRir水平的额外结构。PR在前脑发育中的表达暗示了孕激素和PR参与神经发育的基本机制。(c)威利-利斯公司
Steroid hormones play an influential role in neural development. In addition to androgens and estrogens of fetal and neonatal origin, the developing brain may also be exposed to progesterone. In this regard, identifying forebrain nuclei that are sensitive to progesterone during neural development may elucidate the impact of progesterone on the developing brain. Using immunocytochemistry, the present study documented the distribution of progesterone receptor (PR) expression in the rat forebrain from embryonic day (E) 17 through postnatal day (P) 28. The results indicate that PR expression in the developing brain is extensive, present in numerous forebrain nuclei, but transient, in that PR expression was absent in most nuclei by P28. Regions displaying the highest levels of PR-immunoreactivity (PRir) were found in preoptic and hypothalamic nuclei including the medial preoptic, anteroventral periventricular, arcuate, and ventromedial nuclei. PRir was moderately abundant in the limbic region, particularly in subdivisions of the amygdala, the bed nucleus of the stria terminalis, and hippocampus. The choroid plexus and neocortex were additional structures that demonstrated relatively abundant levels of PRir. The presence PR expression in the developing forebrain implicates the involvement of progesterone and PR in fundamental mechanisms of neural development. (c) Wiley-Liss, Inc.