Estradiol modulation of hepatocyte growth factor by stromal fibroblasts in the female reproductive tract
Estradiol modulation of hepatocyte growth factor by stromal fibroblasts in the female reproductive tract
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DOI：
10.1016/j.fertnstert.2008.10.047
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发表时间：
2009-09-01
影响因子：
6.7
通讯作者：
Fahey, John V.
中科院分区：
文献类型：
--
作者：
Coleman, Kimberly D.;Wright, Jacqueline A.;Fahey, John V.
原代人子宫、宫颈和宫颈外间质成纤维细胞组成性地分泌肝细胞生长因子（HGF），但只有子宫间质成纤维细胞对雌二醇的反应增加HGF的分泌。雌二醇诱导的子宫间质成纤维细胞分泌HGF可能对子宫癌和子宫内膜异位症有重要影响。[j] .中国农业科学（英文版），2009;22(2):391 - 391。(C)2009年美国生殖医学学会。)
Primary human uterine, cervical, and ectocervical stromal fibroblasts constitutively secrete hepatocyte growth factor (HGF), yet only uterine stromal fibroblasts increase HGF secretion in response to estradiol. Estradiol-induced HGF secretion by uterine stromal fibroblasts may have a significant effect on uterine cancer and endometriosis. (Fertil Steril (R) 2009;92:1107-9. (C)2009 by American Society for Reproductive Medicine.)