Health-related quality of life and well-being in adults with idiopathic inflammatory myopathy
Health-related quality of life and well-being in adults with idiopathic inflammatory myopathy
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DOI：
10.1007/s10067-014-2685-0
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发表时间：
2014-08-01
影响因子：
3.4
通讯作者：
Vilardell-Tarres, Miquel
中科院分区：
文献类型：
--
作者：
Armadans-Tremolosa, Imma;Selva-O'Callaghan, Albert;Vilardell-Tarres, Miquel
与健康有关的生活质量（HRQoL）和福祉是试图客观地捕捉一个人对活力和能量的主观感知的概念。我们的目的是确定在我们门诊就诊的诊断为炎症性肌病的成年患者的HRQoL和幸福感，并调查这些概念的临床和生物学相关性。这项横断面研究评估了62例患者（52名女性），平均年龄为50.7岁，其中47例患有皮肌炎，15例患有多发性肌炎。使用国际肌炎评估和临床研究验证的工具评估疾病损害和活动。采用手工肌肉试验评估肌力。使用适用于西班牙人群的世卫组织工具（世卫组织生活质量测量（WHOQOL-BREF））评估生活质量，并使用世卫组织五幸福指数（WHO-5）评估幸福感。进行t检验以检查HRQoL和幸福感结果与几种疾病和患者相关变量的差异。采用Pearson相关系数进行相关分析。所分析的临床或生物学变量均未与较差的HRQoL或幸福感显著相关。两个肌炎亚组（皮肌炎与多发性肌炎）的HRQoL或WHO-5幸福感评分没有差异。疾病活动性和肌肉无力分别与HRQoL的物理和环境域呈负相关（p < 0.002），但与健康无关。病程对HRQoL和幸福感没有显著影响。在成年肌炎患者中，疾病活动性和肌肉无力分别与身体健康和环境领域较差的HRQoL相关。
Health-related quality of life (HRQoL) and well-being are concepts that attempt to objectively capture a person's subjective perceptions of vitality and energy. Our objectives were to determine HRQoL and well-being in adult patients diagnosed with inflammatory myopathy who attended at our outpatient clinic and to investigate clinical and biological correlations with these concepts. Sixty-two patients (52 women), with a mean age of 50.7 years, were evaluated in this cross-sectional study-47 with dermatomyositis and 15 with polymyositis. Disease damage and activity were assessed with the International Myositis Assessment and Clinical Studies-validated instruments. Manual muscle testing was used to evaluate muscle strength. Quality of life was evaluated with the WHO instrument (WHO Quality of Life Measure (WHOQOL-BREF)), adapted for use in the Spanish population, and well-being with the WHO-Five Well-Being Index (WHO-5). t tests were conducted to examine differences in HRQoL and well-being outcomes in relation to several disease- and patient-related variables. Correlation analyses were performed with the Pearson correlation coefficient. None of the clinical or biological variables analyzed was significantly associated with a poorer HRQoL or well-being. No differences in HRQoL or WHO-5 well-being score were found between the two myositis subgroups (dermatomyositis vs. polymyositis). Disease activity and muscle weakness were negatively associated with the physical and environmental domains of the HRQoL, respectively (p < 0.002), but not with well-being. Disease duration did not have a significant impact on HRQoL or well-being. In adult patients with myositis, disease activity and muscle weakness are associated with poorer HRQoL in the physical health and environmental domains, respectively.