Fabrication of Non-phospholipid Liposomal Nanocarrier for Sustained-Release of the Fungicide Cymoxanil.
Fabrication of Non-phospholipid Liposomal Nanocarrier for Sustained-Release of the Fungicide Cymoxanil.
复制标题
用于缓释杀菌剂霜脲氰的非磷脂脂质体纳米载体的制备
DOI：
10.3389/fmolb.2021.627817
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发表时间：
2021
影响因子：
5
通讯作者：
Cui ZK
中科院分区：
文献类型：
--
作者：
Zhang Z;Yang J;Yang Q;Tian G;Cui ZK
脂质体纳米载体可用于解决农药不稳定、降解快、有效期短等问题。具有抗真菌活性的Cymoxanil由于其降解问题，需要理想的载药系统。本文以胆固醇和硬脂胺为原料制备了农药纳米载体非磷脂脂质体，并用场发射扫描电子显微镜、X-射线粉末衍射仪、傅立叶变换红外光谱仪、粒度分布和ζ-电位对其进行了表征。结果表明，环氧苯丙胺成功地负载了立体小体。载药率为92.6%，药脂比为0.0761。药物释放时间延长为3天，改善了药物本身的短效性。在培养基中加入负载环氧西尼的甾体可以有效地抑制酵母细胞的生长，酵母细胞是真菌的模型靶标。立体小体作为纳米载体显著提高了环磷酰胺的稳定性和药效，从而为新型农药制剂的制备引入了实用和经济上理想的策略。
Liposome nanocarriers can be used to solve problems of pesticide instability, rapid degradation and a short period of efficacy. Cymoxanil with antifungal activity requires an ideal drug loading system due to its degradation issues. In this paper, cholesterol and stearylamine were used to prepare non-phospholipid liposomes (sterosomes) as a pesticide nanocarrier, and were characterized with field emission scanning electron microscopy (FE-SEM), X-ray powder diffraction (XRD), Fourier-transform infrared (FT-IR) spectrometer, size distribution, and ζ-potential. The results showed sterosomes were successfully loaded with cymoxanil. The loading efficiency and the drug-to-lipid ratio were 92.6% and 0.0761, respectively. Prolonged drug release was obtained for 3 days, improving the short duration of the drug itself. The addition of cymoxanil-loaded sterosomes in culture medium effectively inhibited the growth of yeast cells, which serve as model fungal targets. Sterosomes as nanocarriers significantly improved the stability and efficacy of cymoxanil, thus introducing practical and economically desirable strategies for the preparation of novel pesticide formulations.