INFLUENCE OF GENOTYPE AND AGE ON ACUTE ACOUSTIC TRAUMA AND RECOVERY IN CBA/CA AND C57BL/6J MICE
INFLUENCE OF GENOTYPE AND AGE ON ACUTE ACOUSTIC TRAUMA AND RECOVERY IN CBA/CA AND C57BL/6J MICE
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DOI：
10.3109/00016489209137496
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发表时间：
1992-11-01
影响因子：
1.4
通讯作者：
LI, HS
中科院分区：
文献类型：
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作者：
LI, HS
两种近交系小鼠，CBA/Ca（在生命后期开始出现中度听力损伤）和C57BL/6J（在成年早期开始出现进行性听力退化），在1、3或6个月大时暴露于120分贝声压级的宽带噪声（2 - 7千赫兹）中5分钟。在暴露后的第一天（复合阈移，CTS）和1个月（永久性阈移，PTS）时通过听性脑干反应测定复合阈移和永久性阈移。随着年龄增长，CBA小鼠在中频（8和12.5千赫兹）对CTS的敏感性降低，但C57小鼠仍保持敏感性。C57小鼠受CTS的影响比年龄匹配的CBA小鼠更严重。在C57小鼠中，噪声诱导的CTS与暴露前阈值呈正相关，在所有年龄和品系中与PTS也呈正相关。然而，从CTS到PTS的恢复量与年龄和品系无关。通过高频暴露前阈值将CBA小鼠误判为C57小鼠的风险仅为2%，而通过CTS误判的风险约为40%。结果表明，遗传易感性能够以一种系统性的方式影响对听力退化和噪声损伤的敏感性，从而可以通过暴露前听力检查，特别是高频检查来识别易感个体。
Two inbred strains of mice, CBA/Ca (with a moderate auditory impairment starting late in life) and C57BL/6J (with a progressive auditory degeneration starting during young adulthood). were exposed to a 120 dB SPL broadband noise (2-7 kHz) for 5 min at the age of 1, 3, or 6 months. Compound and permanent threshold shifts (CTS and PTS) were determined by auditory brainstem response during the first day (CTS) and 1 month (PTS) after exposure. With increasing age. susceptibility to CTS at middle frequencies (8 and 12.5 kHz) decreased in CBA mice. yet was retained in C57 mice. C57 mice were more severely affected by CTS than age-matched CBA mice. Noise-induced CTS was positively correlated to pre-exposure thresholds in C57 mice and to PTS over all ages and strains. The amount of recovery from CTS to PTS was. however, independent of age and strain. There was only a 2% risk of classifying CBA mice as C57 mice by pre-exposure thresholds at high frequency, while there was about 40% risk by CTS. The results indicate that genetic predisposition can affect susceptibility to auditory degeneration and noise impairment in a systematic manner, allowing the identification of susceptible individuals by pre-exposure audiometric examination. especially at high frequencies.