Seroprevalence of herpes simplex virus-2 in suburban primary care offices in the United States
Seroprevalence of herpes simplex virus-2 in suburban primary care offices in the United States
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DOI：
10.1097/01.olq.0000123651.84697.d6
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发表时间：
2004-05-01
影响因子：
3.1
通讯作者：
Justus, S
中科院分区：
文献类型：
--
作者：
Leone, P;Fleming, DT;Justus, S
目的：本研究的目的是估计在相对富裕的郊区初级保健医生（PCP）办公室就诊的成年人的加权样本中单纯疱疹病毒-2 （HSV-2）的血清患病率。目标：在相对富裕的地区，许多pcp认为国家估计的2型单纯疱疹病毒血清流行率不能代表他们的患者群体。本研究旨在测量这些患者人群中HSV-2的血清患病率。研究设计：我们对大约5400名年龄在18至59岁之间的个体进行了横断面研究。在美国6个城市的36个PCP办事处招募个体，并使用Focus酶联免疫吸附法检测HSV-2。计算机辅助问卷用于评估与生殖器疱疹相关的危险行为。结果：5452例可分析血液样本中，HSV-2的总体加权血清阳性率为25.5%（95%可信区间为20.2-30.8%）。只有11.9%的hsv -2血清阳性患者报告有生殖器疱疹史。结论：结果表明，在这种情况下，需要加强郊区PCP和患者对HSV-2高血清患病率的认识。
Objective: The objective of this study was to estimate herpes simplex virus-2 (HSV-2) seroprevallence from a weighted sample of adults attending relatively affluent, suburban primary care physician (PCP) offices.Goal: Many PCPs in relatively affluent areas do not believe national estimates of HSV-2 seroprevallence are representative of their patient populations. This study aimed to measure HSV-2 seroprevalence in these patient populations.Study Design: We conducted a cross-sectional study with approximately 5400 individuals aged 18 to 59 years. Individuals were recruited at 36 PCP offices in 6 U.S. cities and tested for HSV-2 using Focus enzyme-linked immunosorbent assay. A computer-assisted questionnaire was used to assess risk behaviors associated with genital herpes.Results: Among 5452 individuals who provided an analyzable blood sample, the overall weighted HSV-2 seroprevalence was 25.5% (95% confidence interval, 20.2-30.8%). Only 11.9% of HSV-2-seropositive patients reported a history of genital herpes.Conclusions: Results illustrate the need for greater suburban PCP and patient awareness of the high HSV-2 seroprevallence in this setting.