Blood Flow Assessment by Ultrasound‐Induced Destruction of Echocontrast Agents Using Harmonic Power Doppler Imaging: Which Parameters Determine Contrast Replenishment Curves?
Blood Flow Assessment by Ultrasound‐Induced Destruction of Echocontrast Agents Using Harmonic Power Doppler Imaging: Which Parameters Determine Contrast Replenishment Curves?
复制标题
使用谐波功率多普勒成像通过超声诱导破坏回声造影剂来评估血流：哪些参数决定造影剂补充曲线？
DOI：
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Klaus Tiemann
中科院分区：
文献类型：
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作者：
J. Köster;Thomas Schlosser;C. Pohl;Christoph Lentz;S. Lohmaier;Christian Veltmann;S. Kuntz‐Hehner;Heyder Omran;B. Lüderitz;Harald Becher;Klaus Tiemann
目的：评价谐波能量多普勒成像（H-PDI）通过对比剂补充进行血流测定的可行性。背景：指示剂稀释原理在超声造影中的应用受到许多方法问题的限制。最近，引入了一种新方法，该方法依赖于超声介导的微泡破坏和对比剂补充的评价。研究方法：将一种正在开发的全氟化碳衍生造影剂-去甲肾上腺素连续注入稳流体模，并在硅胶管（d = 8 mm）内进行H-PDI配准。破坏和成像帧之间的补充间隔从0.04-2秒不等。使用指数数学模型进行非线性曲线拟合。结果如下：在所有设置下，发现造影剂剂量与最大信号强度之间以及流量与补充曲线的斜率变量β之间存在强线性相关性（r > 0.96）。最大信号强度和对比度补充率被发现是发射功率的函数，并受到深度和焦点位置的显着影响。结论：证明了使用H-PDI获得的补充曲线进行血流评估的可行性。然而，在实验条件下，流动分析受到超声系统设置和成像条件（如发射功率、声场几何形状和调查深度）的严重影响。对于临床应用这种有前途的方法，算法，考虑到特定的系统设置和成像条件下，必须found. Imaging模态，使最均匀的扫描场是最适合的对比剂补充的评估。
Objective: To evaluate the feasibility of flow determinations by contrast replenishment using harmonic power Doppler imaging (H‐PDI). Background: The application of indicator dilution principles on contrast echocardiography is limited by numerous methodical problems. Recently, a new method was introduced that relies on ultrasound‐mediated microbubble destruction and evaluation of the contrast replenishment. Methods: Definity, a perfluorocarbon‐derived contrast agent under development, was continuously infused into a steady flow phantom and H‐PDI registrations were performed within a silicone tube (d = 8 mm). Replenishment interval between destruction and imaging frame was varied from 0.04–2 seconds. Nonlinear curve fitting was performed using an exponential mathematical model. Results: Strong linear correlation between contrast dose and maximum signal intensity as well as between flow and the slope variable β of the replenishment curve was found for all settings (r > 0.96). Maximum signal intensity and contrast replenishment rate were found to be a function of emission power and were significantly influenced by depth and focus position. Conclusion: The feasibility of flow assessment using replenishment curves obtained by H‐PDI was demonstrated. However, in experimental conditions, flow analysis was severely influenced by ultrasound system settings and imaging conditions such as emission power, sound field geometry, and investigation depth. For a clinical use of this promising approach, algorithms that take specific system settings and imaging conditions into account have to be found. Imaging modalities that enable a most homogeneous scan field are best suited for the assessment of contrast replenishment.
功率多普勒谐波成像：评估心肌灌注新技术的可行性研究。
影响因子：
4.8
作者：
Senior,R;Kaul,S;Soman,P;Lahiri,A
通讯作者：
Lahiri,A
影响因子：
37.8
作者：
K. Wei;A. Jayaweera;S. Firoozan;A. Linka;D. Skyba;S. Kaul
通讯作者：
K. Wei;A. Jayaweera;S. Firoozan;A. Linka;D. Skyba;S. Kaul
体内回声对比注射的多普勒定量。
影响因子：
2.9
作者：
Hartley,CJ;Cheirif,J;Collier,KR;Bravenec,JS;Mickelson,JK
通讯作者：
Mickelson,JK