Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK
Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK
复制标题
下调miR-625通过靶向ILK抑制胃癌侵袭和转移
DOI：
10.1016/j.febslet.2012.05.050
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发表时间：
2012-07-30
期刊：
影响因子：
3.5
通讯作者：
Liu, Bingya
中科院分区：
文献类型：
--
作者：
Wang, Ming;Li, Chenglong;Liu, Bingya
越来越多的证据表明，microRNA参与了癌症发生和发展的多个过程。在此，我们报告miR-625的表达显著下调，并与胃癌淋巴结转移呈负相关。miR-625在体内外均能显著抑制胃癌细胞的侵袭和转移。此外，我们确定ILK是miR-625的直接靶基因，并且ILK的敲低具有miR-625过表达的表型。综上所述，我们的研究结果表明，miR-625在肿瘤转移机制中起着重要作用。(c)2012年欧洲生物化学学会联合会。Elsevier B. V.出版，保留所有权利。
Accumulating evidence has shown that microRNAs are involved in multiple processes in cancer development and progression. Here, we report that expression of miR-625 is significantly down-regulated and negatively correlated with lymph node metastasis in gastric cancer. miR-625 significantly inhibits invasion and metastasis of gastric cancer cells both in vitro and in vivo. Moreover, we identify that ILK is a direct target gene for miR-625 and knockdown of ILK has a phenocopy of overexpression of miR-625. Taken together, our findings suggest that miR-625 plays an important role in the mechanism of tumor metastasis. (c) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.