Nonadherence to antiepileptic drugs and increased mortality Findings from the RANSOM Study
Nonadherence to antiepileptic drugs and increased mortality Findings from the RANSOM Study
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DOI：
10.1212/01.wnl.0000319693.10338.b9
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发表时间：
2008-11-11
期刊：
影响因子：
9.9
通讯作者：
Cunnington, M. C.
中科院分区：
文献类型：
--
作者：
Faught, E.;Duh, M. S.;Cunnington, M. C.
目的：主要目的是调查抗癫痫药物（AED）的不依从性是否与死亡率增加相关，次要目的是检查不依从性是否增加严重临床事件的风险，包括急诊（艾德）就诊、住院、机动车事故（MVA）损伤、骨折和头部损伤。方法：采用回顾性开放队列设计，使用1997年1月至2006年6月来自佛罗里达、爱荷华州和新泽西的医疗补助索赔数据。选择了年龄>= 18岁、神经科医生诊断>= 1次癫痫和>= 2次AED药房配药的患者。药物拥有率（MPR）用于评估AED的依从性，MPR >= 0.80视为依从性，
Objectives: The primary objective was to investigate whether nonadherence to antiepileptic drugs (AEDs) is associated with increased mortality and the secondary objective to examine whether nonadherence increases the risk of serious clinical events, including emergency department (ED) visits, hospitalizations, motor vehicle accident (MVA) injuries, fractures, and head injuries.Methods: A retrospective open-cohort design was employed using Medicaid claims data from Florida, Iowa, and New Jersey from January 1997 through June 2006. Patients aged >= 18 years with >= 1 diagnosis of epilepsy by a neurologist and >= 2 AED pharmacy dispensings were selected. Medication possession ratio (MPR) was used to evaluate AED adherence on a quarterly basis with MPR >= 0.80 considered adherent and