Multiscale Model Predicts Tissue-Level Failure From Collagen Fiber-Level Damage
Multiscale Model Predicts Tissue-Level Failure From Collagen Fiber-Level Damage
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DOI：
10.1115/1.4007097
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发表时间：
2012-09-01
影响因子：
1.7
通讯作者：
Barocas, Victor H.
中科院分区：
文献类型：
--
作者：
Hadi, Mohammad F.;Sander, Edward A.;Barocas, Victor H.
过度的组织水平的力传递到软组织的微观结构和细胞外基质，可能导致损伤和失败，通过不了解的物理过程是多尺度的性质。在这项工作中，我们提出了胶原软组织失效的多尺度力学模型，该模型结合了微观结构的空间异质性，并将离散胶原纤维的失效与组织的物质反应联系起来。该模型基于来自不同胶原凝胶几何形状的实验失效数据，能够预测I型胶原凝胶的力学响应和失效，并且它证明了基于纤维的离散失效规则（微米尺度）可以强烈地塑造凝胶的宏观失效响应（毫米尺度）。该模型可作为预测软组织和工程组织类似物宏观破坏条件的有用工具。此外，该多尺度模型为研究基于纤维的复杂机械系统的破坏提供了框架。(DOI: 10.1115/1.4007097)
Excessive tissue-level forces communicated to the microstructure and extracellular matrix of soft tissues can lead to damage and failure through poorly understood physical processes that are multiscale in nature. In this work, we propose a multiscale mechanical model for the failure of collagenous soft tissues that incorporates spatial heterogeneity in the microstructure and links the failure of discrete collagen fibers to the material response of the tissue. The model, which is based on experimental failure data derived from different collagen gel geometries, was able to predict the mechanical response and failure of type I collagen gels, and it demonstrated that a fiber-based rule (at the micrometer scale) for discrete failure can strongly shape the macroscale failure response of the gel (at the millimeter scale). The model may be a useful tool in predicting the macroscale failure conditions for soft tissues and engineered tissue analogs. In addition, the multiscale model provides a framework for the study of failure in complex fiber-based mechanical systems in general. [DOI: 10.1115/1.4007097]