Clinical feasibility of 90Y digital PET/CT for imaging microsphere biodistribution following radioembolization
Clinical feasibility of 90Y digital PET/CT for imaging microsphere biodistribution following radioembolization
复制标题
90Y 数字 PET/CT 用于放射栓塞后微球生物分布成像的临床可行性
DOI：
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发表时间：
2017
影响因子：
9.1
通讯作者：
M. Knopp
中科院分区：
文献类型：
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作者：
C. Wright;K. Binzel;Jun Zhang;E. Wuthrick;M. Knopp
目的本研究的目的是评估下一代固态数字光子计数 PET/CT (dPET/CT) 技术的临床可行性以及与标准护理 (SOC) 轫致辐射 SPECT/CT (bSPECT/CT) 相比，90Y 微球放射栓塞术后患者的影像学结果。方法 5 例患者在常规放射栓塞术后立即接受 SOC 90Y 轫致辐射成像。 3.5 ± 1.7 GBq 90Y 标记的玻璃微球。所有患者还在放射栓塞后 29 ± 11 小时接受 dPET/CT 成像。配对比较用于比较 dPET/CT 和 bSPECT/CT 图像之间的图像质量、图像对比度和 90Y 生物分布。还比较了在 dPET/CT 和 bSPECT/CT 图像上使用不同等轮廓阈值对 90Y 活动进行的体积评估。结果数字 PET/CT 始终提供比 bSPECT/CT 更好的视觉图像质量和 90Y 与背景图像对比度，同时描绘 90Y 生物分布。等轮廓体积评估使用 1% 阈值精确勾画出 dPET/CT 图像上的 90Y 活动和治疗体积，而 bSPECT/CT 图像上需要更严格的 20% 阈值才能获得可比较的治疗体积。与 dPET/CT 图像上的 1% 阈值相比，在 bSPECT/CT 图像上使用限制性较小的 10% 阈值等轮廓严重高估了治疗体积。 结论 数字 PET/CT 在评估放射栓塞后的 90Y 微球生物分布方面在临床上是可行的，并且在采集时间相当的情况下，比常规 bSPECT/CT 提供更好的视觉图像质量和图像对比度。通过进一步优化和临床验证，dPET 技术可以对 90Y 微球生物分布进行更快、更准确的基于成像的评估。
PurposeThe purpose of this study was to evaluate the clinical feasibility of next generation solid-state digital photon counting PET/CT (dPET/CT) technology and imaging findings in patients following 90Y microsphere radioembolization in comparison with standard of care (SOC) bremsstrahlung SPECT/CT (bSPECT/CT).MethodsFive patients underwent SOC 90Y bremsstrahlung imaging immediately following routine radioembolization with 3.5 ± 1.7 GBq of 90Y-labeled glass microspheres. All patients also underwent dPET/CT imaging at 29 ± 11 h following radioembolization. Matched pairs comparison was used to compare image quality, image contrast and 90Y biodistribution between dPET/CT and bSPECT/CT images. Volumetric assessments of 90Y activity using different isocontour thresholds on dPET/CT and bSPECT/CT images were also compared.ResultsDigital PET/CT consistently provided better visual image quality and 90Y-to-background image contrast while depicting 90Y biodistribution than bSPECT/CT. Isocontour volumetric assessment using a 1% threshold precisely outlined 90Y activity and the treatment volume on dPET/CT images, whereas a more restrictive 20% threshold on bSPECT/CT images was needed to obtain comparable treatment volumes. The use of a less restrictive 10% threshold isocontour on bSPECT/CT images grossly overestimated the treatment volume when compared with the 1% threshold on dPET/CT images.ConclusionsDigital PET/CT is clinically feasible for the assessment of 90Y microsphere biodistribution following radioembolization, and provides better visual image quality and image contrast than routine bSPECT/CT with comparable acquisition times. With further optimization and clinical validation, dPET technology may allow faster and more accurate imaging-based assessment of 90Y microsphere biodistribution.