Intrauterine growth restriction affects the preterm infant's hippocampus
Intrauterine growth restriction affects the preterm infant's hippocampus
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DOI：
10.1203/pdr.0b013e318165c005
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发表时间：
2008-04-01
影响因子：
3.6
通讯作者：
Hueppi, Petra S.
中科院分区：
文献类型：
--
作者：
Lodygensky, Gregory A.;Seghier, Mohammed L.;Hueppi, Petra S.
已知海马体易受缺氧、应激和营养不良的影响，所有这些都可能存在于胎儿宫内生长受限（IUGR）中。采用3D磁共振成像技术研究了足月新生儿IUGR对海马的影响。将13例胎盘功能不全后出生的IUGR早产儿与13例胎龄匹配的正常宫内生长年龄的早产儿进行比较。海马结构的差异，定义使用基于体素的形态测量和手动分割。在足月和校正年龄24个月时，采用Bayley婴幼儿发育量表对早产儿的特定神经行为功能进行评估。基于体素的形态测定法检测到两组之间海马体的灰质体积存在显著差异。这一发现证实了人工分割的海马与IUGR后海马体积减少。在早产儿行为评估的所有六个子域中，海马体积减小与足月等效年龄的功能行为差异进一步相关，但在校正年龄24个月时则无关。我们的结论是，海马发育IUGR的改变，可能是由于母体皮质类固醇激素暴露，低氧血症和微量营养素缺乏的组合。
The hippocampus is known to be vulnerable to hypoxia, stress, and undernutrition, all likely to be present in fetal intrauterine growth restriction (IUGR). The effect of IUGR in preterm infants on the hippocampus was studied using 3D magnetic resonance imaging at term-equivalent age Thirteen preterm infants born with IUGR after placental insufficiency were compared with 13 infants with normal intrauterine growth age matched for gestational age. The hippocampal structural differences were defined using voxel-based morphometry and manual segmentation. The specific neurobehavioral function was evaluated by the Assessment of Preterm Infants' Behavior at term and at 24 mo of corrected age by a Bayley Scales of Infant and Toddler Development. Voxel-based morphometry detected significant gray matter volume differences in the hippocampus between the two groups. This finding was confirmed by manual segmentation of the hippocampus with a reduction of hippocampal volume after IUGR. The hippocampal volume reduction was further associated with functional behavioral differences at term-equivalent age in all six subdomains of the Assessment of Preterm Infants' Behavior but not at 24 mo of corrected age. We conclude that hippocampal development in IUGR is altered and might result from a combination of maternal corticosteroid hormone exposure, hypoxemia, and micronutrient deficiency.