Asymmetric N-Allylic Alkylation of Hydrazones with Morita–Baylis–Hillman Carbonates
Asymmetric N-Allylic Alkylation of Hydrazones with Morita–Baylis–Hillman Carbonates
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DOI：
10.1002/adsc.201400790
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发表时间：
2015-02
影响因子：
5.4
通讯作者：
L. Yao;Chun‐Jiang Wang
中科院分区：
文献类型：
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作者：
L. Yao;Chun‐Jiang Wang
本文首次在改性金鸡烷生物碱催化下，与森田-贝利斯-希尔曼（MBH）碳酸酯进行了n -烯丙基不对称烷基化反应，得到了产率高的n -取代腙，具有独特的区域选择性和优异的对映选择性。随后的烯丙基烷基化产物转化为合成有用的吡唑烷酮。
The first asymmetricN‐allylic alkylation of hydrazones with Morita‐Baylis–Hillman (MBH) carbonates catalyzed by modifiedCinchonaalkaloids has been developed, affordingN‐substituted hydrazones in good yields with exclusive regioselectivities and excellent enantioselectivities. Subsequent transformations of the allylic alkylation products led to synthetically useful pyrazolidinones.