Chorea as a form of presentation of human immunodeficiency virus‐associated dementia complex
Chorea as a form of presentation of human immunodeficiency virus‐associated dementia complex
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舞蹈病是人类免疫缺陷病毒相关痴呆症的一种表现形式
DOI：
10.1212/wnl.50.2.568
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发表时间：
1998
期刊：
影响因子：
9.9
通讯作者：
E. V. de Seijas
中科院分区：
文献类型：
--
作者：
J. Pardo;A. Marcos;H. Bhathal;M. Castro;E. V. de Seijas
掩盖了有利于他克林的定量措施的积极发现。由于服用较低剂量他克林的患者中有较大比例被送入住院机构，因此受到的影响更为严重，因此将这些患者排除在随访评估之外将低估较高剂量他克林对定量终点的影响。另一方面，如果根据这些定量指标，两年后他克林确实没有带来任何好处，那么由自然流失造成的不确定性也会削弱“没有好处”的说法。由于疾病在两年内下降，以及随后的自然减员，传统的为期 6 个月的临床试验中对轻度至中度疾病严重程度的患者使用的精神状态检查或功能评估不足以作为长期临床试验中的结果衡量标准。使用生存分析和范围更广的仪器的结果测量技术更适合长期抗 AD 药物试验。最近发表的司来吉兰、α-生育酚和安慰剂的对照试验？是此方法的另一个应用的示例。正如我们的研究中所见，后一项研究3在主要终点和日常生活活动的延迟方面有好处，但在认知测试分数方面没有好处。
have obscured positive findings on the quantitative measures favoring tacrine. Because a greater percentage of patients on lower tacrine doses were institutionalized, and hence more severely affected, the exclusion of these patients from follow-up assessments would underestimate the effect of higher doses of tacrine on the quantitative end points. On the other hand, if there were truly no benefits from tacrine after 2 years on these quantitative measures, the uncertainty created by attrition weakens the claim of no benefits also. Because of disease decline over 2 years, and subsequent attrition, mental status examinations or functional assessments used in traditional 6-month clinical trials in patients with mild to moderate disease severity are inadequate as outcome measures in long-term clinical trials. Outcome measurement techniques that use survival analyses and instruments with broader ranges are preferable for long-duration anti-AD drug trials. The recently published controlled trial of selegiline, a-tocopherol, and placebo? is an example of another application of this methodology. As was seen in our study,’ there were benefits in this latter study3 in terms of delays in primary end points and activities of daily living, but no benefits in terms of cognitive test scores.