The D1 receptor antagonist, SCH 23390, induces signs of parkinsonism in African green monkeys.
The D1 receptor antagonist, SCH 23390, induces signs of parkinsonism in African green monkeys.
复制标题
D1 受体拮抗剂 SCH 23390 可诱导非洲绿猴出现帕金森病症状。
DOI：
10.1016/0024-3205(91)90299-q
复制
发表时间：
1991
期刊：
影响因子：
6.1
通讯作者：
Roth,RH
中科院分区：
文献类型：
--
作者：
Lawrence,MS;RedmondJr,DE;Elsworth,JD;Taylor,JR;Roth,RH
系统地给予选择性的D1拮抗剂SCH 23390，导致健康的非洲绿猴的运动发生显著变化。这些影响包括帕金森氏症的运动冻结、不协调、运动迟缓、运动乏力、震颤和眨眼频率降低。给MPTP治疗的猴子服用SCH 23390会增加现有的帕金森症。根据最近的数据，这一结果特别令人感兴趣，这些数据证明了一种完整的D1激动剂双氢利定在缓解MPTP治疗的猴子帕金森症方面的有效性。这些数据表明D1受体与帕金森氏病所损害的功能有关，并提示在临床使用该或类似的D1受体拮抗剂治疗精神疾病时，可能会出现帕金森病副作用。
Systematic administration of the selective D1antagonist, SCH 23390, caused significant motor changes in healthy African green monkeys. The effects included the parkinsonian signs of motor freezing, incoordination, bradykinesia, poverty of movement, tremor and depressed blink rate. SCH 23390 administered to MPTP-treated monkeys increased existing parkinsonism. The results are of particular interest in light of recent data that demonstrate the effectiveness of dihydrexidine, a full D1agonist, in alleviating parkinsonism in MPTP-treated monkeys. These data implicate D1receptors in the functions impaired by Parkinson's disease and suggest the possibility of parkinsonian side effects in the clinical use of this or similar D1antagonists as treatments for psychiatric disorders.