Serological Response of Japanese Children and Old People to Japanese B Encephalitis Mouse Brain Vaccine
Serological Response of Japanese Children and Old People to Japanese B Encephalitis Mouse Brain Vaccine
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日本儿童和老人对乙型脑炎鼠脑疫苗的血清学反应
DOI：
10.3181/00379727-65-15890
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发表时间：
1947
影响因子：
--
通讯作者：
R. Schlesinger
中科院分区：
文献类型：
--
作者：
A. Sabin;D. R. Ginder;M. Matumoto;R. Schlesinger
对居住在日本冈山流行区3至5岁的日本儿童和60岁以上的老年人进行了日本乙型脑炎小鼠脑疫苗接种，每次接种2剂，每次1cc，间隔6天，在预计可能爆发该病的季节之前，在第一次接种后一个月接种第三剂，每次接种1cc。接种前均无抗体，10例接种50%免疫原剂量（ID30） 0.013 cc（小鼠试验）疫苗10 d后均出现中和抗体，而接种ID50为0.077 cc的10例中仅有1例出现显著的中和指数。然而，在接种前无抗体的7名老年人中，接种相同剂量的更好的疫苗（ID30为0.013 cc），没有产生中和或补体固定抗体。在疫苗中出现了针对鼠脑成分的补体固定抗体，也出现了针对日本B病毒的补体固定抗体，但在接种了较好的疫苗的10名儿童中，有5名儿童的日本B抗原滴度明显较高。补体固定抗体是针对日本乙型病毒的特异性抗体，在接种前具有中和抗体（既往隐性感染的证据）的所有10名老年人中迅速出现，但在没有这种抗体的9名老年人中没有出现。
Summary Japanese children, 3 to 5 years old, and people, over 60 years of age, living in the endemic region of Okayama, Japan, were given commercial Japanese B encephalitis mouse brain vaccine—2 doses of 1 cc each, 6 days apart, and a 3rd dose of 1 cc one month after the first dose in advance of the season when outbreaks of the disease may be expected. None of the children had antibodies before vaccination, and of the 10, who were inoculated with a vaccine having a 50% immunogenic dose (ID30) of 0.013 cc by mouse assay, all had neutralizing antibodies 10 days after the 3rd dose, while only 1 of the 10, who received a vaccine with an ID50 of 0.077 cc, developed a significant neutralization index. However, in a group of 7 old people, without antibodies before inoculation, who received the same dosage of the better vaccine (ID30 of 0.013 cc) none developed neutralizing or complement-fixing antibodies. Complement-fixing antibodies for the mouse brain component appeared as well as for the Japanese B virus contained in the vaccine, but in 5 of the 10 children, inoculated with the better vaccine, the titers were significantly higher with the Japanese B antigen. Complement-fixing antibodies, specific for the Japanese B virus, appeared rapidly in all of the 10 old people who had neutralizing antibodies (evidence of previous inapparent infection) prior to inoculation, but in none of the 9 old people who were without such antibodies.