Epstein-Barr virus--associated diseases in humans.
Epstein-Barr virus--associated diseases in humans.
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爱泼斯坦-巴尔病毒——人类相关疾病。
DOI：
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发表时间：
2000
影响因子：
2.1
通讯作者：
Keisei Kawa
中科院分区：
文献类型：
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作者：
Keisei Kawa
30年来，人们已经知道，eb病毒是一种普遍存在的人类疱疹病毒，是急性感染性单核细胞增多症的病原，并与伯基特淋巴瘤和未分化鼻咽癌的发生密切相关。最近的研究表明，EBV还与多种其他疾病有关，如EBV相关的噬血细胞综合征、慢性活动性EBV感染、t细胞淋巴瘤、自然杀伤细胞白血病/淋巴瘤、免疫功能低下宿主的淋巴增生性疾病、霍奇金病、脓胸相关b细胞淋巴瘤、平滑肌肿瘤和胃癌。因此，该病毒继续引起全世界的注意，现在重新评估EBV与人类疾病之间的关系是适当的。本文综述了近年来eb病毒的研究进展和eb病毒相关疾病的临床发现，为开发新的治疗策略提供依据。
It has been known for 30 years that Epstein-Barr virus (EBV), a ubiquitous human herpesvirus, is the etiologic agent of acute infectious mononucleosis and is closely associated with the genesis of Burkitt's lymphoma and undifferentiated nasopharyngeal carcinoma. Recent studies have demonstrated that EBV is also implicated in a variety of other diseases, such as EBV-associated hemophagocytic syndrome, chronic active EBV infection, T-cell lymphoma, natural killer cell leukemia/lymphoma, lymphoproliferative diseases in immunocompromised hosts, Hodgkin's disease, pyothorax-associated B-cell lymphoma, smooth-muscle tumors, and gastric carcinoma. Thus, the virus continues to attract worldwide attention, and it is now appropriate for a reappraisal of the relation between EBV and human diseases. This review summarizes the recent progress in research on EBV and the clinical findings of EBV-associated diseases and provides a basis for the development of new therapeutic strategies.