Bioactive Alkaloids from the Sea: A Review
Bioactive Alkaloids from the Sea: A Review
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DOI：
10.3390/md201039
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发表时间：
2004-02
期刊：
影响因子：
5.4
通讯作者：
M. Kuramoto;H. Arimoto;D. Uemura
中科院分区：
文献类型：
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作者：
M. Kuramoto;H. Arimoto;D. Uemura
在我们不断从海洋生物中寻找生物活性物质的过程中，已经分离出了新的生物碱。从冲绳双壳类贝类中提纯了品那毒素和品那明，它们是一种有效的贝类毒物。平纳曲霉毒素激活钙通道。卤素是从海绵Halichondria okadai中分离得到的。该化合物抑制VCAM-1的诱导。阻断VCAM-1的药物可能对治疗冠状动脉疾病、心绞痛和非心血管炎症性疾病有用。平甲酸也是一种cPLA2的抑制剂，也是从P.Muricata中得到的。有趣的是，品甲酸的结构与卤代氯的结构密切相关。盐酸去甲苯甲胺是从丛生的带状幼虫中分离出来的，能抑制去卵巢小鼠骨量和强度的下降，可能是一种很好的骨质疏松药物。Ircinine是从海绵Ircinia sp.中提纯的一种活性硫酸酯。从链霉菌(Streptomyces sp.)中分离到一种超氧阴离子产生的抑制剂阿伯拉菌素。本文介绍了该课题组最近分离到的具有生物活性的海洋生物碱。
In our ongoing search for bioactive substances from marine organisms, novel alkaloids have been isolated. Pinnatoxins and pinnamine, potent shellfish poisons, were purified from the Okinawan bivalve Pinna muricata. Pinnatoxins activate Ca2+ channels. Halichlorine was isolated from the marine sponge Halichondria okadai. This compound inhibits the induction of VCAM-1. Drugs that block VCAM-1 may be useful for treating coronary artery diseases, angina, and noncardiovascular inflammatory diseases. Pinnaic acids, which are cPLA2 inhibitors, were also obtained from P. muricata. Interestingly, the structures of pinnaic acids are closely related to that of halichlorine. Norzoanthamine hydrochloride, isolated from the colonial zoanthid Zoanthus sp., suppresses decreases in bone weight and strength in ovariectomized mice, and could be a good candidate for an osteoporotic drug. Ircinamine, purified from the marine sponge Ircinia sp., has a reactive thioester. Aburatubolactams, inhibitors of superoxide anion generation, were isolated from Streptomyces sp. This article covers the bioactive marine alkaloids that have been recently isolated by this research group.