Calcium ion homeostasis in urinary bladder smooth muscle.

Calcium ion homeostasis in urinary bladder smooth muscle.
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膀胱平滑肌中的钙离子稳态。

DOI:
10.1007/978-1-4615-4737-2_12
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发表时间:
1999
影响因子:
--
通讯作者:
Chacko,S
Chacko,S
中科院分区:
医学4区
文献类型:
--
作者:
Zderic,SA;Gong,C;Desanto,M;Hypolite,J;Hutcheson,J;Wein,AJ;Chacko,S

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膀胱的目的是在低压下储存尿液,并允许在适当的时间,地点和社交场合有效排出。为了满足这些复杂的需求,下尿路的主要组成部分必须以统一的方式相互作用。表1列出了影响膀胱主动(收缩)和被动(抗变形)性能的基本元素。值得注意的是,即使膀胱的被动特性在一定程度上也是由肌动蛋白-肌球蛋白相互作用决定的,这种相互作用是钙介导的,依赖于能量。这些组件中的任何一个(通常是几个)的故障都将导致清空或存储失败,或者它们的某些组合失败。尽管该表中的每个成分都对膀胱的生物学特性有重要贡献,但本文的目的将集中在肌浆网(SR)起主要作用的细胞钙调节的作用上。
The purpose of the urinary bladder is to store urine at low pressures, and allow for effective evacuation at an appropriate time, location and social situation. For this complex set of requirements to be carried out, it is essential that the major components of the lower urinary tract interact in a unified fashion.1The basic elements of the bladder which contribute to the active (contractile) and passive properties (resistance to deformation) are listed in Table 1. It is important to note that even the passive properties of the urinary bladder are in part determined by actin myosin interactions that are calcium mediated and energy dependent. Failure of any one (usually several) of these components will contribute to a failure to empty or to store, or some combination thereof. Although each component within this table makes an important contribution to shaping the bladder’s biologic properties, the purpose of this review will be to focus on the role of cell calcium regulation in which the sarcoplasmic reticulum (SR) plays a major role.
气管平滑肌毒蕈碱刺激期间肌球蛋白磷酸化和主动张力的解离。
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