Depression and poor glycemic control - A meta-analytic review of the literature
Depression and poor glycemic control - A meta-analytic review of the literature
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DOI：
10.2337/diacare.23.7.934
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发表时间：
2000-07-01
期刊：
影响因子：
16.2
通讯作者：
Clouse, RE
中科院分区：
文献类型：
--
作者：
Lustman, PJ;Anderson, RJ;Clouse, RE
目的：抑郁症在糖尿病患者中很常见，但其与血糖控制的关系尚未得到系统的综述。我们的目的是确定抑郁症是否与血糖控制不良有关。研究设计和方法- Medline和PsycINFO数据库和已发表的参考文献列表被用于识别测量抑郁症与血糖控制相关性的研究。荟萃分析程序被用来转换的结果，以一个共同的度量，计算效果大小（ES），并进行统计分析的集体data.RESULTS -共有24项研究满足纳入和排除标准的荟萃分析。抑郁与高血糖显著相关（Z = 5.4，P < 0.0001）。标准化ES在小至中等范围内（0.17），并且一致，因为95% CI较窄（0.13-0.21）。ES在1型或2型糖尿病的研究中相似（ES 0.19 vs. 0.16），并且当使用标准化访谈和诊断标准而不是自我报告问卷来评估抑郁症时，ES更大（ES 0.28 vs. 0.15）。需要更多的研究来确定这种关系的方向性，并确定抑郁症治疗对血糖控制和糖尿病长期病程的影响。
OBJECTIVE - Depression is common among patients with diabetes, but its relationship to glycemic control has not been systematically reviewed. Our objective was to determine whether depression is associated with poor glycemic control.RESEARCH DESIGN AND METHODS - Medline and PsycINFO databases and published reference lists were used to identify studies that measured the association of depression with glycemic control. Meta-analytic procedures were used to convert the findings to a common metric, calculate effect sizes (ESs), and statistically analyze the collective data.RESULTS - A total of 24 studies satisfied the inclusion and exclusion criteria for the metaanalysis. Depression was significantly associated with hyperglycemia (Z = 5.4, P < 0.0001). The standardized ES was in the small-to-moderate range (0.17) and was consistent, as the 95% CI was narrow (0.13-0.21). The ES was similar in studies of either type 1 or type 2 diabetes (ES 0.19 vs. 0.16) and larger when standardized interviews and diagnostic criteria rather than self-report questionnaires were used to assess depression (ES 0.28 vs. 0.15).CONCLUSIONS - Depression is associated with hyperglycemia in patients with type 1 or type 2 diabetes. Additional studies are needed to establish the directional nature of this relationship and to determine the effects of depression treatment on glycemic control and the long-term course of diabetes.