Absence of dementia in late-onset schizophrenia: a one year follow-up of a Brazilian case series
Absence of dementia in late-onset schizophrenia: a one year follow-up of a Brazilian case series
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DOI：
10.1590/s0004-282x2006000600011
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发表时间：
2006-12-01
影响因子：
1.4
通讯作者：
Mendlowicz, Mauro V.
中科院分区：
文献类型：
--
作者：
Laks, Jerson;Fontenelle, Leonardo F.;Mendlowicz, Mauro V.
背景：晚发性精神分裂症(LOS)患者的认知缺陷被报道为稳定的，尽管一些前瞻性研究表明，一个亚组出现了显著的认知功能下降。来自发展中国家的关于洛杉矶的数据很少。目的：评价巴西LOS患者一年内的认知功能。方法：采用简易智力状态检查(MMSE)、CAMCOG、阳性和阴性症状量表、Pfeffer日常生活能力量表(ADL)和神经精神病量表(NPI)对13例LOS患者在基线和治疗1年后进行评定。结果：1年后患者的认知和日常生活能力基本保持稳定[基线MMSE=21.31(4.87)和CAMCOG=80.31(16.68)；终点MMSE=20.77(3.86)和CAMCOG=82.92(14.42)(Z=-0.831；P=0.40)；基线ADL=4.31(5.65)；终点ADL=5.92(3.86)(Z=-0.831；P=0.40)1；终点NPI=10.54(10.69)(Z=-0.737；P=0.46)]。结论：与发达国家的患者一样，巴西的LOS患者似乎没有患上痴呆症，至少在一年的过程中是这样。
Background: Cognitive deficits of late-onset schizophrenia (LOS) patients have been reported as stable, although some prospective studies show that a sub-group develop a significant cognitive decline. Data on LOS from developing countries are scarce. Objective: To evaluate the cognitive performance of Brazilian patients with LOS over the course of one year. Method: Thirteen LOS patients were evaluated at baseline and after one year with the Mini-Mental State Examination (MMSE), the CAMCOG, the Positive and Negative Symptoms Scale, the Pfeffer's Activities of Daily Living (ADL), and the Neuropsychiatric Inventory (NPI). Results: Cognition and activities of daily living remained stable over the course of one year [baseline MMSE = 21.31 (4.87) and CAMCOG = 80.31 (16.68); end-point MMSE=20.77 (3.86) and CAMCOG=82.92 (14.42) (Z=-0.831; p=0.40); baseline ADL=4.31 (5.65); end-point ADL= 5.92 (3.86) (Z=-0.831; p=0.40)1;end-point NPI=10.54(10.69)(Z=-0.737;p=0.46]. Conclusion: Like patients from developed countries, Brazilian patients with LOS do not seem develop dementia, at least over the course of one year.