DETERMINANTS OF PLASMA VITAMINS AND LIPIDS - THE WORKING WELL STUDY
DETERMINANTS OF PLASMA VITAMINS AND LIPIDS - THE WORKING WELL STUDY
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DOI：
10.1093/oxfordjournals.aje.a117224
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发表时间：
1994-07-15
影响因子：
5
通讯作者：
NICOLOSI, RJ
中科院分区：
文献类型：
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作者：
HEBERT, JR;HURLEY, TG;NICOLOSI, RJ
本研究旨在评估随机选择的203名工人参与工作场所健康干预试验的血浆α-生育酚、β-胡萝卜素、视黄醇和胆固醇组分浓度的决定因素。工人来自马萨诸塞州东部和中部的四家公司，所有人都完成了84项半定量食物频率问卷，作为基线（干预前）自我评估工具的一部分。在空腹采血时，每位参与者还完成了一份简短的筛选问卷，以评估饮食习惯和烟草暴露的变化，并收集有关维生素和营养补充剂使用的数据。根据自我报告的数据，作者发现他们可以解释35%的血浆β-胡萝卜素变异性，73%的α-生育酚变异性，36%的视黄醇变异性和19%的胆固醇变异性。血浆β-胡萝卜素水平似乎受到使用不含胡萝卜素的补充剂的影响，这表明这些制剂中所含的其他制剂具有β-胡萝卜素节省能力。血浆α-生育酚水平未受到类似影响。这些结果与那些使用更密集的饮食评估技术作为比较标准的研究结果相比是有利的。结果进行了讨论，在流行病学研究分析中使用自我报告的数据的影响。
This study was conducted to assess the determinants of plasma concentrations of alpha-tocopherol, beta-carotene, retinol, and cholesterol fractions in a randomly selected subset of 203 workers participating in a worksite-based health intervention trial. Workers were from four companies in eastern and central Massachusetts, and all completed an 84-item semiquantitative food frequency questionnaire as part of baseline (preintervention) self-assessment instruments. At the time of fasting blood sampling, each participant also completed a short screening questionnaire for assessment of changes in dietary habits and tobacco exposure and for collection of data on use of vitamins and nutritional supplements. On the basis of the self-reported data, the authors found that they could explain 35% of the variability in plasma beta-carotene, 73% of the variability in alpha-tocopherol, 36% of the variability in retinol, and 19% of the variability in cholesterol. Plasma beta-carotene levels appeared to be affected by the use of supplements that did not contain carotene, indicating a beta-carotene sparing capability of other agents contained in these preparations. Plasma alpha-tocopherol levels were not similarly affected. These results compare favorably with those from studies that used more intensive dietary assessment techniques as the comparison criterion. Results are discussed in terms of implications for use of self-reported data in epidemiologic study analyses.