Association of maternal thyroid function during early pregnancy with offspring IQ and brain morphology in childhood: a population-based prospective cohort study
Association of maternal thyroid function during early pregnancy with offspring IQ and brain morphology in childhood: a population-based prospective cohort study
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DOI：
10.1016/s2213-8587(15)00327-7
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发表时间：
2016-01-01
影响因子：
44.5
通讯作者：
Peeters, Robin P.
中科院分区：
文献类型：
--
作者：
Korevaar, Tim I. M.;Muetzel, Ryan;Peeters, Robin P.
背景甲状腺激素参与早期脑发育的调节。由于胎儿甲状腺直到妊娠18-20周才完全发挥功能，因此神经元迁移和宫内脑发育的其他关键早期阶段在很大程度上取决于母体甲状腺激素的供应。目前的临床实践主要集中在预防低甲状腺激素浓度的负面影响，但动物研究数据表明，低和高浓度的甲状腺激素对后代大脑发育都有负面影响。我们的目的是调查母亲甲状腺功能与儿童智商（IQ）和脑形态学的关联。方法在这项基于人群的前瞻性队列研究中，嵌入R代研究（鹿特丹，荷兰），我们调查了母亲甲状腺功能与儿童智商（非语言智力测试评估）和脑形态学（脑MRI扫描评估）的关联。符合条件的妇女是那些在分娩日期居住在研究地区的妇女，分娩日期必须在2002年4月1日至2006年1月1日之间。在这项研究中，有血清样本的妇女在怀孕早期（
Background Thyroid hormone is involved in the regulation of early brain development. Since the fetal thyroid gland is not fully functional until week 18-20 of pregnancy, neuronal migration and other crucial early stages of intrauterine brain development largely depend on the supply of maternal thyroid hormone. Current clinical practice mostly focuses on preventing the negative consequences of low thyroid hormone concentrations, but data from animal studies have shown that both low and high concentrations of thyroid hormone have negative effects on off spring brain development. We aimed to investigate the association of maternal thyroid function with child intelligence quotient (IQ) and brain morphology.Methods In this population-based prospective cohort study, embedded within the Generation R Study (Rotterdam, Netherlands), we investigated the association of maternal thyroid function with child IQ (assessed by non-verbal intelligence tests) and brain morphology (assessed on brain MRI scans). Eligible women were those living in the study area at their delivery date, which had to be between April 1, 2002, and Jan 1, 2006. For this study, women with available serum samples who presented in early pregnancy (