Effect of meal and intravenous erythromycin on manometric and electrogastrographic measurements of gastric motor and electrical activity
Effect of meal and intravenous erythromycin on manometric and electrogastrographic measurements of gastric motor and electrical activity
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DOI：
10.1023/a:1005445207628
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发表时间：
2000-03-01
影响因子：
3.1
通讯作者：
Navarro, J
中科院分区：
文献类型：
--
作者：
Faure, C;Wolff, VP;Navarro, J
胃电描记术（EGG）在皮肤表面上测量归因于胃平滑肌细胞的肌电活动。信号幅度和变化的生理意义尚未明确确立。进食后增加的信号幅度可能与收缩活动增加或胃扩张有关。本研究调查了胃运动活动增加，不伴有胃扩张，对EGG记录的影响，并将其与膳食的影响进行比较。9名儿童（3个月至15岁）通过胃窦十二指肠测压评估慢性假性肠梗阻（N = 5）、慢性呕吐（N = 2）和腹胀（N = 2）。同步EGG记录同时进行。在研究过程中，4名儿童被给予一顿饭，5名被给予静脉内红霉素3 mg/kg超过1小时。（MI =波数x振幅总和）餐前1小时测定（或红霉素）至餐后1小时测定（或在静脉内红霉素期间），还计算了电信号在相同时间的运行总谱功率的比率，胃窦MI在餐后[MI比率（平均值+/- se）5.33 +/- 2.2]和静脉注射红霉素后增加（MI比率：9.36 +/- 2.6）。餐后[功率比（平均值+/- SE）3.01 +/- 0.65]和静脉注射红霉素后（功率比：1.23 +/- 0.39），电活动幅度也增加，但餐后增加更大（与静脉注射红霉素相比，P < 0.05）。胃窦MI率与频谱总功率比无相关性。总之，增加幅度的胃电活动记录的胃电饭后似乎只是部分由于胃窦运动活动的增加。功率的增加也与胃扩张有关。
Electrogastrography (EGG) measures, on the skin surface, the myoelectrical activity attributable to gastric smooth muscle cells. The physiological significance of signal amplitude and variation has not been clearly established. The increased signal amplitude after eating a meal may be related to increased contractile activity or to gastric distension. This study investigates the effect of increased gastric motor activity, unaccompanied by gastric distension, on the EGG recording and compares it to the effect of a meal. Nine children (3 months to 15 years old), were assessed by antroduodenal manometry for chronic intestinal pseudoobstruction (N = 5), chronic vomiting (N = 2), and abdominal distension (N = 2). Synchronized EGG recording was performed simultaneously. During the study, four children were given a meal and five were given intravenous erythromycin 3 mg/kg over 1 hr. The ratio of the antral motor index (MI = number of waves x sum of amplitudes) determined 1 hr before a meal (or erythromycin) to that determined 1 hr after a meal (or during intravenous erythromycin) was calculated, The ratio of the running total spectrum power of the electrical signal at the same times was also calculated, Antral MI increased after a meal [MI ratio (mean +/- se) 5.33 +/- 2.2] and after intravenous erythromycin (MI ratio: 9.36 +/- 2.6). The amplitude of the electrical activity also increased after the meal [power ratio (mean +/- SE) 3.01 +/- 0.65] and after intravenous erythromycin (power ratio: 1.23 +/- 0.39), but the increase was greater after the meal(P < 0.05 vs intravenous erythromycin). No correlation was found between antral MI ratio and running total spectrum power ratio. In conclusion, the increased amplitude of the gastric electrical activity recorded by the EGG after a meal seems to be only partly due to the increase in antral motor activity. The increase in power is also related to gastric distension.